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Generic Name: nizatidine (ni ZA ti deen)
Brand Names: Axid AR
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Drug Information:
Axid AR (nizatidine) is non-prescription medicine that contains nizatidine. Nizatidine is a histamine-2 blocker that works by decreasing the amount of acid produced by the stomach. Axid AR works by reducing the production of stomach acid that can cause heartburn. Axid AR may also be used for purposes not listed in this medication guide. Axid AR can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. You should not use Axid AR if you are allergic to nizatidine or similar medications such as ranitidine (Zantac), cimetidine (Tagamet), or famotidine (Pepcid). Learn more

Axid Side Effects

Axid AR Side Effects

Note: This document contains side effect information about nizatidine. Some of the dosage forms listed on this page may not apply to the brand name Axid AR.

For the Consumer

Applies to nizatidine: oral capsules, oral tablets for

Side effects include:

Headache, dizziness.

For Healthcare Professionals

Applies to nizatidine: oral capsule, oral solution, oral tablet


The most commonly reported side effects included headache, rhinitis, abdominal pain, and diarrhea.

Nervous system

Very common (10% or more): Headache (up to 16.6%)

Common (1% to 10%): Dizziness, somnolence

Frequency not reported: Seizure

A pediatric patient given 2.5 mg/kg orally 2 times a day for 23 days experienced an EEG-diagnosed seizure during treatment.


Common (1% to 10%): Constipation, diarrhea, dry mouth, dyspepsia, flatulence, gastrointestinal disorder, nausea, nausea and vomiting, tooth disorder, vomiting


Common (1% to 10%): Cough, cough increased, nasal congestion, nasopharyngitis, pharyngitis, rhinitis, sinusitis

Postmarketing reports: Bronchospasm, laryngeal edema


Common (1% to 10%): Accident, asthenia, fever, injury, pain, pyrexia, surgical procedure


Common (1% to 10%): Abnormal dreams, anxiety, insomnia, irritability, nervousness

Postmarketing reports: Decreased libido, reversible mental confusion


Common (1% to 10%): Pruritus, rash, sweating, urticaria

Postmarketing reports: Exfoliative dermatitis


Common (1% to 10%): Back pain, myalgia

Postmarketing reports: Arthralgia


Common (1% to 10%): Infection

Rare (0.01% to 0.1%): Serum sickness, serum sickness-like reactions


Common (1% to 10%): Chest pain

Frequency not reported: Short episodes of asymptomatic ventricular tachycardia

Postmarketing reports: Vasculitis


Common (1% to 10%): Anorexia

Postmarketing reports: Hyperuricemia unrelated to gout or nephrolithiasis


Common (1% to 10%): Amblyopia


Fatal thrombocytopenia was reported in a patient who experienced possible drug-related thrombocytopenia previously received this drug and another histamine-2 (H2) receptor antagonist.

Uncommon (0.1% to 1%): Anemia

Postmarketing reports: Agranulocytosis, eosinophilia, fatal thrombocytopenia, leukopenia, thrombocytopenic purpura


Rare (0.01% to 0.1%): Transient, marked transaminase elevations, transient, marked alkaline phosphatase elevations

Frequency not reported: Elevated liver enzyme tests (alkaline phosphatase, ALT, AST), hepatocellular injury, transient, asymptomatic transaminase elevations, transient, asymptomatic alkaline phosphatase elevations

Postmarketing reports: Cholestatic injury, cholestatic injury with jaundice, hepatitis, jaundice, mixed hepatocellular injury, mixed hepatocellular injury with jaundice

Some patients developed ALT and/or AST elevations exceeding 500 international units/L, with a report of an ALT level exceeding 2000 international units/L.

Some patients 2 to 18 years developed mild elevations in serum transaminase levels (1 to 2 times the upper limit of normal).

Liver enzyme elevations and liver abnormalities were reversible upon discontinuation of treatment.


Hypersensitivity reactions included bronchospasm, eosinophilia, laryngeal edema, and rash.

Postmarketing reports: Anaphylaxis, hypersensitivity reactions


Postmarketing reports: Impotence


Postmarketing reports: Gynecomastia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Axid