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Generic Name: doxylamine and pyridoxine (dox IL a meen and PIR i DOX een)
Brand Name: Bonjesta, Diclegis
Physician reviewed Bonjesta patient information - includes Bonjesta description, dosage and directions.
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Drug Information:
Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Pyridoxine is a form of vitamin B (B6). Bonjesta is a combination medicine used to treat nausea and vomiting during pregnancy, sometimes called morning sickness. Bonjesta may also be used for purposes not listed in this medication guide. Do not use Bonjesta if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Learn more

Bonjesta Side Effects

Bonjesta Side Effects

Note: This document contains side effect information about doxylamine / pyridoxine. Some of the dosage forms listed on this page may not apply to the brand name Bonjesta.

For the Consumer

Applies to doxylamine / pyridoxine: oral tablet delayed release, oral tablet extended release

Along with its needed effects, doxylamine/pyridoxine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking doxylamine / pyridoxine:

Incidence not known

  • Blurred or loss of vision
  • burning feeling while urinating
  • chest discomfort
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult or labored breathing
  • difficult or painful urination
  • disturbed color perception
  • double vision
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • halos around lights
  • headache, severe and throbbing
  • hives, itching, skin rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • night blindness
  • overbright appearance of lights
  • redness of the skin
  • stomach distension or pain
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • tunnel vision

Some side effects of doxylamine / pyridoxine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Unusual drowsiness

Incidence not known

  • Anxiety
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion about identity, place, and time
  • constipation
  • diarrhea
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • general feeling of discomfort or illness
  • headache
  • increased sweating
  • irritability
  • nightmares
  • sensation of spinning
  • trouble sleeping
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to doxylamine / pyridoxine: oral delayed release tablet, oral tablet extended release


Postmarketing reports: Palpitation, tachycardia


Postmarketing reports: Hyperhidrosis, pruritus, rash, maculo-papular rash


Postmarketing reports: Abdominal distension, abdominal pain, constipation, diarrhea


Postmarketing reports: Hypersensitivity

Nervous system

Very common (10% or more): Somnolence (14.3%)

Postmarketing reports: Vertigo, dizziness, headache, migraines, paresthesia, psychomotor hyperactivity


Postmarketing reports: Blurred vision, visual disturbances


Postmarketing reports: Chest discomfort, fatigue, irritability, malaise


Postmarketing reports: Anxiety, disorientation, insomnia, nightmares


Postmarketing reports: Dysuria, urinary retention


Postmarketing reports: Dyspnea

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Bonjesta