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Butisol sodium

Generic Name: butabarbital (byoo ta BAR bi tal)
Brand Name: Butisol Sodium
Physician reviewed Butisol Sodium patient information - includes Butisol Sodium description, dosage and directions.
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Drug Information:
Butisol Sodium is a barbiturate (bar-BIT-chur-ate). This medicine slows the activity of your brain and nervous system. Butisol Sodium is used as a sedative. This medicine is also used short-term to treat insomnia, or as a sedative before surgery. Butisol Sodium may also be used for purposes not listed in this medication guide. You should not use Butisol Sodium if you have porphyria. You should not use Butisol Sodium if you are allergic to it, or if you have: porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system). Learn more

Butisol sodium Side Effects

Butisol Sodium Side Effects

Note: This document contains side effect information about butabarbital. Some of the dosage forms listed on this page may not apply to the brand name Butisol Sodium.

For the Consumer

Applies to butabarbital: oral tablet

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Mental, mood, or behavior changes that are new or worse.
  • Shortness of breath.
  • Very upset stomach or throwing up.
  • Worse trouble sleeping.
  • Feeling nervous and excitable.
  • Hallucinations (seeing or hearing things that are not there).
  • Not thinking clearly.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling sleepy.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to butabarbital: oral elixir, oral tablet

Nervous system

Nervous system side effects have included somnolence, headache, confusion, hyperkinesias, ataxia, and dizziness.


Cardiovascular side effects have included bradycardia, hypotension, and syncope.


Gastrointestinal side effects have included nausea, vomiting, and constipation.


Hypersensitivity reactions have included angioedema, skin rash, and exfoliative dermatitis.


Oncologic side effects have included a possible increased frequency of malignancy (particularly liver cancer and brain tumors) following use of phenobarbital and other barbiturates.


Other side effects have included physical and psychological dependence. Withdrawal symptoms have been reported when butabarbital (the active ingredient contained in Butisol Sodium) therapy has been discontinued suddenly.


Psychiatric side effects have included agitation, nightmares, nervousness, psychiatric disturbance, hallucinations, insomnia, anxiety, and abnormal thinking.


Respiratory side effects have included hypoventilation and apnea.

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Butisol Sodium