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Generic Name: acamprosate (a KAM proe sate)
Brand Names: Campral
Campral is used to help people with alcohol dependence quit drinking alcohol. Learn about side effects, interactions and indications.
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Drug Information:
Campral (acamprosate) affects chemicals in the brain that may be unbalanced in a person who is addicted to alcohol. Acamprosate works by restoring this chemical balance in the brain in an alcohol-dependent person who has recently quit drinking. Campral is used together with behavior modification and counseling support to help a person who has recently quit drinking alcohol continue to choose not to drink. Campral is not likely to be helpful if you have not already quit drinking or undergone detoxification. It may not help you if you are also addicted to other substances besides alcohol. Learn more

Campral Side Effects

Campral Side Effects

Note: This document contains side effect information about acamprosate. Some of the dosage forms listed on this page may not apply to the brand name Campral.

For the Consumer

Applies to acamprosate: oral tablet delayed release

Along with its needed effects, acamprosate (the active ingredient contained in Campral) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acamprosate:

More common

  • Extreme feeling of sadness or emptiness
  • fear
  • severe depression

Symptoms of Overdose

Get emergency help immediately if any of the following symptoms of overdose occur while taking acamprosate:

  • Abdominal pain
  • confusion
  • constipation
  • diarrhea
  • dry mouth
  • headache
  • incoherent speech
  • increased urination
  • metallic taste
  • muscle weakness
  • nausea
  • thirst
  • unusual tiredness
  • vomiting
  • weight loss

Some side effects of acamprosate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Discouragement
  • feeling sad
  • irritability
  • lack of appetite
  • lack or loss of strength
  • loss of interest or pleasure
  • nervousness
  • sleeplessness
  • tiredness
  • trouble concentrating
  • trouble sleeping

Less common

  • Accidental injury
  • bloated or full feeling
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • dizziness
  • dry mouth
  • excess air or gas in stomach or intestines
  • itching skin
  • pain
  • passing gas
  • sweating

For Healthcare Professionals

Applies to acamprosate: oral delayed release tablet


The most commonly reported side effects included diarrhea, insomnia, anxiety, depression, and asthenia.


Very common (10% or more): Diarrhea (up to 17%)

Common (1% to 10%): Abdominal pain, constipation, dry mouth, dyspepsia, flatulence, nausea, vomiting

Uncommon (0.1% to 1%): Dysphagia, eructation, esophagitis, gastritis, gastroenteritis, gastrointestinal hemorrhage, hematemesis, nausea and vomiting, pancreatitis, rectal hemorrhage

Rare (0.01% to 0.1%): Abdomen enlarged, ascites, cholecystitis, colitis, duodenal ulcer, increased salivation, melena, mouth ulceration, stomach ulcer

Nervous system

Common (1% to 10%): Amnesia, dizziness, headache, paresthesia, somnolence, syncope, taste perversion, tremor

Uncommon (0.1% to 1%): Convulsion, hypesthesia, migraine, neuralgia, vertigo

Rare (0.01% to 0.1%): Encephalopathy, hyperkinesia, twitching


Common (1% to 10%): Abnormal thinking, anxiety, depression, insomnia, libido decreased, suicide attempt

Uncommon (0.1% to 1%): Abnormal dreams, agitation, apathy, confusion, hallucinations, hostility, intentional injury, intentional overdose, libido increased, neurosis, suicidal ideation, withdrawal syndrome

Rare (0.01% to 0.1%): Alcohol craving, depersonalization, manic reaction, paranoid reaction, psychosis

Frequency not reported: Nervousness


Common (1% to 10%): Chest pain, hypertension, palpitations, peripheral edema, vasodilation

Uncommon (0.1% to 1%): Angina pectoris, hemorrhage, hypotension, myocardial infarct, phlebitis, postural hypotension, tachycardia, varicose vein

Rare (0.01% to 0.1%): Cardiomyopathy, deep thrombophlebitis, heart failure, mesenteric arterial occlusion, shock


Common (1% to 10%): Bronchitis, cough increased, dyspnea, pharyngitis, rhinitis

Uncommon (0.1% to 1%): Asthma, epistaxis, pneumonia

Rare (0.01% to 0.1%): Laryngismus, pulmonary embolus


Common (1% to 10%): Pruritus, maculopapular rash, rash, sweating

Uncommon (0.1% to 1%): Acne, alopecia, dry skin, ecchymosis, eczema, exfoliative dermatitis, urticaria, vesiculobullous rash/vesiculobullous eruptions

Rare (0.01% to 0.1%): Face edema, photosensitivity reaction, psoriasis


Common (1% to 10%): Accidental injury, asthenia, chills, pain

Uncommon (0.1% to 1%): Deafness, fever, hernia, malaise, tinnitus

Rare (0.01% to 0.1%): Sudden death


Common (1% to 10%): Anorexia, increased appetite, weight gain

Uncommon (0.1% to 1%): Avitaminosis, diabetes mellitus, gout, hyperglycemia, hyperuricemia, thirst, weight loss

Rare (0.01% to 0.1%): Hyponatremia, lactic dehydrogenase increased


Common (1% to 10%): Arthralgia, back pain, myalgia

Uncommon (0.1% to 1%): Leg cramps, neck pain

Rare (0.01% to 0.1%): Myopathy, rheumatoid arthritis, torticollis

Frequency not reported: Fracture


Common (1% to 10%): Frigidity, impotence

Uncommon (0.1% to 1%): Metrorrhagia, sexual function abnormal, urinary frequency, urinary incontinence, urinary tract infection, vaginitis

Rare (0.01% to 0.1%): Abnormal ejaculation, hematuria, menorrhagia, nocturia, polyuria, urinary urgency


Common (1% to 10%): Flu syndrome, infection

Uncommon (0.1% to 1%): Abscess


Common (1% to 10%): Abnormal vision

Uncommon (0.1% to 1%): Amblyopia

Rare (0.01% to 0.1%): Diplopia, ophthalmitis, photophobia


Uncommon (0.1% to 1%): ALT increased, AST increased, bilirubinemia, hepatitis, liver cirrhosis, liver function tests abnormal

Rare (0.01% to 0.1%): Alkaline phosphatase increased


Uncommon (0.1% to 1%): Anemia, eosinophilia, lymphocytosis, thrombocytopenia

Rare (0.01% to 0.1%): Leukopenia, lymphadenopathy, monocytosis


Uncommon (0.1% to 1%): Allergic reaction

Very rare (less than 0.01%): Anaphylactic reactions, angioedema, hypersensitivity reactions


Rare (0.01% to 0.1%): Creatinine increased, kidney calculus

Postmarketing reports: Acute kidney failure

Acute kidney failure was reported in 3 patients and was temporally associated with treatment.


Rare (0.01% to 0.1%): Goiter, hypothyroidism


Rare (0.01% to 0.1%): Carcinoma of liver

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Campral