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Generic Name: bicalutamide (bye ka LOO ta mide)
Brand Names: Casodex
Casodex (bicalutamide) is an anti-androgen and is used together with LHRH to treat prostate cancer. Includes Casodex side effects, interactions and indications.
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Drug Information:
Casodex (bicalutamide) is an anti-androgen. It works in the body by preventing the actions of androgens (male hormones). Casodex is used together with another hormone to treat prostate cancer. Casodex may also be used for purposes not listed in this medication guide. Casodex is used to treat prostate cancer. This medicine should never be taken by a woman or a child. Casodex can harm your liver. Call your doctor at once if you have nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). Learn more

Casodex Side Effects

Casodex Side Effects

Note: This document contains side effect information about bicalutamide. Some of the dosage forms listed on this page may not apply to the brand name Casodex.

In Summary

Common side effects of Casodex include: abdominal pain, nausea, and mastalgia. Other side effects include: flu-like symptoms, gynecomastia, vomiting, and anorexia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to bicalutamide: oral tablet

Along with its needed effects, bicalutamide (the active ingredient contained in Casodex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bicalutamide:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine
  • blurred vision
  • body aches or pain
  • chills
  • congestion
  • cough
  • cough producing mucus
  • difficult or labored breathing
  • dizziness
  • dryness or soreness of the throat
  • fever
  • headache
  • hoarseness
  • lower back or side pain
  • nervousness
  • painful or difficult urination
  • pounding in the ears
  • rapid weight gain
  • runny nose
  • slow or fast heartbeat
  • sweating
  • tender, swollen glands in the neck
  • tightness in the chest
  • tingling of the hands or feet
  • trouble with swallowing
  • unusual weight gain or loss
  • voice changes

Less common

  • Abnormal growth filled with fluid or semisolid material
  • ankle, knee, or great toe joint pain
  • arm, back, or jaw pain
  • bleeding from the rectum or bloody stools
  • blindness
  • bloody nose
  • burning feeling while urinating
  • burning, tingling, numbness, or pain in the hands, arms, feet, or legs
  • change in bowel habits
  • chest pain, discomfort, tightness or heaviness
  • confusion
  • decrease in frequency of urination
  • decrease in urine volume
  • decreased vision
  • difficulty in passing urine (dribbling)
  • difficulty with swallowing or eating
  • dilated neck veins
  • dry mouth
  • fainting
  • irregular breathing or heartbeat
  • joint stiffness or swelling
  • lightheadedness
  • loss of appetite
  • lump or swelling in the abdomen or stomach
  • nausea
  • no blood pressure or pulse
  • noisy breathing
  • pain or discomfort in the arms, jaw, back, or neck
  • painful blisters on the trunk of the body
  • persistent, non-healing sore
  • rapid, shallow breathing
  • reddish patch or irritated area
  • sensation of pins and needles
  • shiny bump
  • stabbing pain
  • stomach discomfort
  • stopping of the heart
  • sunken eyes
  • thirst
  • tumor
  • unconsciousness
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting
  • weight gain
  • white, yellow, or waxy scar-like area
  • wrinkled skin
  • yellow skin or eyes

Incidence not known

  • Bleeding gums
  • coughing up blood
  • hives or welts, itching, skin rash
  • increased menstrual flow or vaginal bleeding
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • redness of the skin

Some side effects of bicalutamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Belching
  • breast pain
  • constipation
  • decreased interest in sexual intercourse
  • diarrhea
  • difficulty with moving
  • dry skin
  • hair loss or thinning of the hair
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • leg cramps
  • loss in sexual ability, desire, drive, or performance
  • loss of strength or energy
  • muscle ache, cramp, pain, or weakness
  • pain in the pelvis
  • pain or tenderness around the eyes and cheekbones
  • passing of gas
  • sleepiness or unusual drowsiness
  • stomach pain or fullness
  • stuffy or runny nose
  • swelling of the breasts or breast soreness in both females and males

For Healthcare Professionals

Applies to bicalutamide: oral tablet


Very common (10% or more): Pain (35%), asthenia (22%), peripheral edema (13%)

Common (1% to 10%): Weight loss, weight gain, fever, chills, hernia, cyst


Very common (10% or more): Hot flashes (53%)

Common (1% to 10%): Chest pain, hypertension, angina pectoris, congestive heart failure, myocardial infarction, coronary arrest, coronary artery disorder, syncope


In patients with advanced prostate cancer treated with this drug in combination with an LHRH analog, the most frequent adverse reaction was hot flashes (53%).


Very common (10% or more): Constipation (22%), pelvic pain (21%), nausea (15%), diarrhea (12%), abdominal pain (11%)

Common (1% to 10%): Dyspepsia, flatulence, vomiting, melena, rectal hemorrhage, dry mouth, dysphagia, GI disorder, periodontal abscess, GI carcinoma


Common (1% to 10%): Increased liver enzyme test, alkaline phosphatase increased, elevated AST, elevated ALT, elevated bilirubin


Very common (10% or more): Nocturia (12%), hematuria (12%)

Common (1% to 10%): Urinary tract infection, gynecomastia, impotence, breast pain, urinary frequency, urinary retention, urinary impaired, urinary incontinence, decreased libido, dysuria, urinary urgency, hydronephrosis, urinary tract disorder


Common (1% to 10%): Anorexia, hyperglycemia, bone pain, myasthenia, edema, BUN Increased, creatinine increased, dehydration, gout, hypercholesteremia


Very common (10% or more): Anemia (11%)

Common (1% to 10%): Decreased hemoglobin, decreased white cell count

Postmarketing reports: Increased PT/INR due to interaction between coumarin anticoagulants and this drug; serious bleeding reported


Common (1% to 10%): Elevated creatinine


Very common (10% or more): Back pain (25%)

Common (1% to 10%): Paresthesia, neck pain, leg cramps, myalgia

Nervous system

Common (1% to 10%): Headache, neuropathy, hypertonia


Very common (10% or more): Dyspnea (13%)

Common (1% to 10%): Cough, pharyngitis, bronchitis, pneumonia, rhinitis

Uncommon (0.1% to 1%): Lung disorder, asthma, epistaxis, sinusitis

Postmarketing reports: Interstitial lung disease (sometimes fatal) including interstitial pneumonitis and pulmonary fibrosis, most often at doses greater than 50 mg


Common (1% to 10%): Rash, sweating, dry skin, alopecia, pruritus, herpes zoster, skin carcinoma, skin disorder

Postmarketing reports: Photosensitivity


Very common (10% or more): Infection (18%)

Common (1% to 10%): Influenza syndrome


Common (1% to 10%): Specified cataract


Common (1% to 10%): Insomnia, anxiety, depression, confusion, somnolence, nervousness


Common (1% to 10%): Neoplasm

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Casodex