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Generic Name: complement C1 esterase inhibitor (KOM ple ment C1 ES ter ase in HIB it or)
Brand Names: Cinryze
Cinryze (complement C1 esterase inhibitor) is used to prevent attacks of angioedema in people with hereditary angioedema (HAE). Cinryze information includes side effects, news and clinical trial results.
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Drug Information:
Cinryze (complement C1 esterase inhibitor) is a man-made form of a protein that occurs naturally in the blood stream and helps control swelling in the body. People with a condition called hereditary angioedema do not have enough of this protein. Hereditary angioedema can cause attacks of swelling and symptoms such as stomach problems or trouble breathing. Cinryze is used to prevent attacks of angioedema. The Berinert brand of complement C1 esterase inhibitor is used to treat attacks of angioedema. Learn more

Cinryze Side Effects

Cinryze Side Effects

Note: This document contains side effect information about C1 esterase inhibitor (human). Some of the dosage forms listed on this page may not apply to the brand name Cinryze.

In Summary

Common side effects of Cinryze include: headache. Other side effects include: abdominal pain, nausea, vomiting, and muscle spasm. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to C1 esterase inhibitor (human): intravenous powder for solution

Other dosage forms:

  • powder for solution

Along with its needed effects, C1 esterase inhibitor (human) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking C1 esterase inhibitor (human):

Less common

  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Incidence not known

  • Cough
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • hives, itching, or skin rash
  • pains in the chest, groin, or legs, especially calves of the legs
  • severe headaches of sudden onset
  • shortness of breath
  • sudden loss of coordination
  • sudden onset of shortness of breath for no apparent reason
  • sudden onset of slurred speech
  • sudden vision changes
  • tightness in the chest
  • unusual tiredness or weakness

Some side effects of C1 esterase inhibitor (human) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache

Less common

  • Back pain
  • burning sensation on the skin
  • diarrhea
  • feeling of constant movement of self or surroundings
  • nausea
  • sensation of spinning
  • sneezing

Incidence not known

  • Abdominal or stomach pain

For Healthcare Professionals

Applies to C1 esterase inhibitor (human): intravenous kit, intravenous powder for injection, subcutaneous powder for injection


Respiratory side effects have included sinusitis, bronchitis, upper respiratory tract infection, and viral upper respiratory tract infection.

Nervous system

Nervous system side effects have included headache.


Musculoskeletal side effects have included limb injury, back pain, and pain in extremity.


Dermatologic side effects have included pruritus.


Cardiovascular side effects have included postmarketing reports of thrombotic events including deep vein thrombosis, myocardial infarction, and transient ischemic attack.

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Cinryze