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Generic Name: isavuconazonium (EYE sa vue KOE na ZOE nee um)
Brand Names: Cresemba
Cresemba (isavuconazonium sulfate) is used to treat invasive aspergillosis and invasive mucormycosis. Includes Cresemba side effects, interactions and indications.
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Drug Information:
Cresemba (isavuconazonium) is an antifungal medication that fights infections caused by fungus. Cresemba is used to treat infections caused by certain types of fungus (aspergillosis or mucormycosis). Cresemba may also be used for purposes not listed in this medication guide. You should not use Cresemba if you have a genetic heart rhythm disorder called "Short QT syndrome." Many drugs can interact with isavuconazonium, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Cresemba. Learn more

Cresemba Side Effects

Cresemba Side Effects

Note: This document contains side effect information about isavuconazonium. Some of the dosage forms listed on this page may not apply to the brand name Cresemba.

In Summary

Common side effects of Cresemba include: dyspnea, increased serum alanine aminotransferase, increased serum alkaline phosphatase, increased serum aspartate aminotransferase, and increased serum bilirubin. Other side effects include: hypotension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to isavuconazonium: oral capsule

Other dosage forms:

  • intravenous powder for solution

Along with its needed effects, isavuconazonium (the active ingredient contained in Cresemba) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking isavuconazonium:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody urine
  • blurred vision
  • chest pain
  • confusion
  • convulsions
  • decreased frequency or amount of urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast or irregular heartbeat
  • loss of appetite
  • lower back or side pain
  • muscle pain or cramps
  • muscle spasms (tetany) or twitching
  • numbness or tingling in the hands, feet, or lips
  • seizures
  • severe nausea or vomiting
  • sweating
  • tightness in the chest
  • tingling of the hands or feet
  • trembling
  • trouble breathing
  • unusual tiredness or weakness

Less common or rare

  • Cough or hoarseness
  • dark urine
  • fever with or without chills
  • hives, itching, or rash
  • irritation
  • joint pain, stiffness, or swelling
  • light-colored stools
  • red, swollen skin
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach pain
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • chills
  • diarrhea
  • red skin lesions, often with a purple center
  • red, irritated eyes

Some side effects of isavuconazonium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • anxiety
  • back pain
  • headache
  • heartburn or indigestion
  • seeing, hearing, or feeling things that are not there
  • stomach discomfort or upset
  • trouble sleeping
  • unusual excitement, nervousness, or restlessness

Less common or rare

  • Continuing ringing or buzzing or other unexplained noise in the ears
  • decreased vision
  • eye pain
  • feeling of constant movement of self or surroundings
  • hair loss or thinning of the hair
  • hearing loss
  • sensation of spinning

For Healthcare Professionals

Applies to isavuconazonium: intravenous powder for injection, oral capsule


The most common side effects were nausea, vomiting, diarrhea, headache, elevated liver chemistry tests, hypokalemia, constipation, dyspnea, cough, peripheral edema, and back pain. Serious side effects were reported in 55% of patients. Therapy was permanently discontinued due to side effects in 14% of patients; confusional state, acute renal failure, increased blood bilirubin, convulsion, dyspnea, epilepsy, respiratory failure, and vomiting led to permanent discontinuation most often.


Very common (10% or more): Nausea (up to 27.6%), vomiting (up to 25%), diarrhea (up to 23.7%), abdominal pain (16.7%), constipation (up to 14%)

Common (1% to 10%): Dyspepsia

Frequency not reported: Abdominal distension, gastritis, gingivitis, stomatitis


Very common (10% or more): Hypokalemia (up to 19.1%)

Common (1% to 10%): Decreased appetite, hypomagnesemia

Frequency not reported: Hypoalbuminemia, hypoglycemia, hyponatremia


Elevated liver transaminases (ALT or AST) greater than 3 times the upper limit of normal (3 x ULN) and greater than 10 x ULN were reported in 4.4% and 1.2% of patients, respectively.

Very common (10% or more): Elevated liver chemistry/laboratory tests (includes increased ALT, AST, blood alkaline phosphatase, blood bilirubin, GGT; up to 17.1%)

Common (1% to 10%): Elevated liver transaminases (ALT or AST)

Frequency not reported: Cholecystitis, cholelithiasis, hepatitis, hepatomegaly, hepatic failure, cholestasis


Very common (10% or more): Dyspnea (up to 17.1%), cough (12%)

Common (1% to 10%): Acute respiratory failure

Frequency not reported: Bronchospasm, tachypnea

Nervous system

Very common (10% or more): Headache (up to 17%)

Frequency not reported: Convulsion, epilepsy, dysgeusia, encephalopathy, hypoesthesia, migraine, peripheral neuropathy, paresthesia, somnolence, stupor, syncope, tremor, tinnitus, vertigo


Very common (10% or more): Peripheral edema (up to 15.2%), fatigue (10.5%)

Common (1% to 10%): Chest pain

Frequency not reported: Infusion-related reactions (including hypotension, dyspnea, chills, dizziness, paresthesia, hypoesthesia), catheter thrombosis, malaise, chills, fall


Very common (10% or more): Insomnia (10.5%)

Common (1% to 10%): Delirium (includes agitation, confusional state, delirium, disorientation, mental status changes), anxiety

Frequency not reported: Confusion, hallucination, depression


Very common (10% or more): Renal failure (10.1%)

Frequency not reported: Acute renal failure


Very common (10% or more): Back pain (up to 10.1%)

Frequency not reported: Myositis, bone pain, neck pain


Common (1% to 10%): Hypotension

Frequency not reported: Atrial fibrillation, atrial flutter, bradycardia, reduced QT interval on ECG, palpitations, supraventricular extrasystoles, supraventricular tachycardia, ventricular extrasystoles, cardiac arrest, thrombophlebitis


Common (1% to 10%): Rash, pruritus

Frequency not reported: Alopecia, dermatitis, exfoliative dermatitis, erythema, petechiae, urticaria


Common (1% to 10%): Injection site reaction


Frequency not reported: Agranulocytosis, leukopenia, pancytopenia


Frequency not reported: Hypersensitivity


Frequency not reported: Hematuria, proteinuria


Frequency not reported: Optic neuropathy

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Cresemba