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Generic Name: difluprednate ophthalmic (DYE floo PRED nate off THAL mik)
Brand Names: Durezol
Durezol (difluprednate) is used to treat pain and swelling following eye surgery. Includes Durezol side effects, interactions and indications.
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Drug Information:
Durezol (difluprednate ophthalmic emulsion) is a corticosteroid medicine. It prevents the release of substances in the body that cause inflammation. Durezol ophthalmic emulsion is used to treat eye pain and inflammation caused by surgery. Durezol is also used to treat anterior uveitis, inflammation that affects the front part of the eye. You should not use Durezol if you have untreated glaucoma, any type of eye infection (including herpes), or an untreated infection in your eyes or elsewhere (including chickenpox). Learn more

Durezol Side Effects

Durezol Side Effects

Note: This document contains side effect information about difluprednate ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Durezol.

For the Consumer

Applies to difluprednate ophthalmic: ophthalmic emulsion

Along with its needed effects, difluprednate ophthalmic (the active ingredient contained in Durezol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking difluprednate ophthalmic:

More common

  • Blurred vision
  • change in color vision
  • decreased vision or other changes in vision
  • difficulty seeing at night
  • eye discomfort
  • eye pain
  • eye redness
  • increase in blood flow to the whites of the eyes
  • increased sensitivity of the eyes to sunlight
  • painful irritation of the front clear part of the eye
  • sensitivity of the eyes to light
  • swelling or redness of the eye and lining of the eyelid

Less common

  • Eyelid irritation and crusting
  • tearing
  • throbbing eye pain
  • watering of the eyes

Some side effects of difluprednate ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Dry eyes


  • Burning, itching, or soreness of the eye
  • feeling of having something in the eye

For Healthcare Professionals

Applies to difluprednate ophthalmic: ophthalmic emulsion


Common (1% to 10%): Corneal edema, ciliary and conjunctival hyperemia, eye pain, photophobia, posterior capsule opacification, anterior chamber cells, anterior chamber flare, conjunctival edema, blepharitis, reduced visual acuity, punctate keratitis, eye inflammation, iritis, blurred vision, eye irritation

Uncommon (0.1% to 1%): Corneal pigmentation and striae, episcleritis, eye pruritus, eyelid irritation and crusting, foreign body sensation, increased lacrimation, macular edema, sclera hyperemia, uveitis, increased intraocular pressure, iritis, limbal and conjunctival hyperemia, dry eye, iridocyclitis


The most commonly reported side effects were elevated intraocular pressure, visual acuity and field defects, and posterior subcapsular cataract formation.


Uncommon (0.1% to 1%): Application site discomfort or irritation

Nervous system

Common (1% to 10%): Headache

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Durezol