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Generic Name: sodium hyaluronate (injection) (SO dee um HYE al yoo RON ate)
Brand Name: Durolane, Euflexxa, Gel-One, Gelsyn-3, Hyalgan, Supartz
Physician reviewed Durolane (injection) (injection) patient information - includes Durolane (injection) description, dosage and directions.
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Drug Information:
Durolane is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints. Durolane is used to treat knee pain caused by osteoarthritis. Durolane is usually given when other arthritis medications have not been effective. Durolane may also be used for purposes not listed in this medication guide. You should not receive a Durolane if you have an infection in your knee or in the skin around your knee. You should not receive Durolane if you are allergic to it, or if you have an infection in your knee or in the skin around your knee. Learn more

Durolane Side Effects

Durolane Side Effects

Note: This document contains side effect information about sodium hyaluronate. Some of the dosage forms listed on this page may not apply to the brand name Durolane.

For the Consumer

Applies to sodium hyaluronate: injection gel/jelly, injection solution

Along with its needed effects, sodium hyaluronate (the active ingredient contained in Durolane) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium hyaluronate:

Less common

  • Blue color or flushing or redness of skin
  • cough
  • difficulty in swallowing
  • dizziness or feeling faint (severe)
  • fever
  • redness or pain at place of injection
  • skin rash, hives, and/or itching
  • stuffy nose
  • swelling of eyelids, face, or lips
  • tightness in chest, troubled breathing, and/or wheezing

Some side effects of sodium hyaluronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • headache
  • itching of the skin
  • large, nonelevated blue or purplish patches in the skin
  • loss of appetite
  • nausea and/or vomiting
  • stomach pain
  • swelling of the knee

For Healthcare Professionals

Applies to sodium hyaluronate: intra-articular solution


Common (1% to 10%): Injection site pain/swelling/effusion/redness/warmth

Uncommon (0.1% to 1%):


Frequency not reported: Hayfever reaction on face and neck, reaction on forearms and knees

Postmarketing reports: Anaphylaxis/anaphylactoid reaction


Frequency not reported: Swelling of the face/eyelids/mouth/extremities, fever


Common (1% to 10%): Nausea, vomiting, abdominal pain, diarrhea, dyspepsia


Frequency not reported: Transient hypotension


Very common (10% or more): Arthralgia (18%), arthropathy/arthrosis/arthritis (11%)

Common (1% to 10%): Back pain, leg discomfort, leg pain


Common (1% to 10%): Influenza-like reaction


Common (1% to 10%): Urinary tract infection


Common (1% to 10%): Upper respiratory tract infection, sinusitis, bronchitis, rhinitis

Nervous system

Common (1% to 10%): Headache, dizziness


Frequency not reported: Rash, itching

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Durolane