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Generic Name: naloxone (nah LOX one)
Brand Names: Evzio, Narcan
Evzio (naloxone) is an auto-injector used to reverse opioid overdose. Includes Evzio side effects, interactions and indications.
  • Prescription Settings

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Drug Information:
Evzio (naloxone) blocks or reverses the effects of opioid medication, including extreme drowsiness, slowed breathing, or loss of consciousness. An opioid is sometimes called a narcotic. Evzio auto-injector is a prescription medicine used for the treatment of an opioid emergency such as an overdose with signs of breathing problems and severe sleepiness or not being able to respond. Evzio should not be used in place of emergency medical care for an overdose. Naloxone is also used to help diagnose whether a person has used an overdose of an opioid. Learn more

Evzio Side Effects

Evzio Side Effects

Note: This document contains side effect information about naloxone. Some of the dosage forms listed on this page may not apply to the brand name Evzio.

For the Consumer

Applies to naloxone: injection solution

Other dosage forms:

  • nasal spray

Along with its needed effects, naloxone (the active ingredient contained in Evzio) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking naloxone:

Incidence not known

  • Abdominal or stomach cramps
  • body aches
  • convulsions
  • diarrhea
  • difficult or troubled breathing
  • excessive crying
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • goosebumps
  • increased or excessive unconscious or jerking movements
  • irregular, fast or slow, or shallow breathing
  • irritability
  • nausea or vomiting
  • nervousness
  • pale or blue lips, fingernails, or skin
  • restlessness
  • runny nose
  • shivering
  • sneezing
  • sweating
  • trembling
  • weakness
  • yawning

For Healthcare Professionals

Applies to naloxone: compounding powder, injectable solution, nasal spray


This drug may precipitate abrupt opioid withdrawal in physically dependent persons; signs and symptoms may include body aches, fever, sweating, sneezing, yawning, nausea, vomiting, sweating, lacrimation, rhinorrhea, cramping, insomnia, chills/hot flashes, piloerection, tachycardia, anxiety, restlessness, irritability, tremulousness, hypertension, seizures, and cardiac arrest. In the neonate, opioid withdrawal may also include convulsions, excessive crying, and hyperactive reflexes.


In postoperative patients, many of whom had cardiovascular disease, the following cardiovascular side effects have been reported: hypotension, hypertension, atrial and ventricular tachycardia, ventricular fibrillation, left ventricular failure, and cardiac arrest. Death, coma, and encephalopathy have been reported as sequelae of these events.

Common (1% to 10%): Tachycardia, hypotension, hypertension

Uncommon (0.1% to 1%): Arrhythmia, bradycardia

Rare (less than 0.1%): Fibrillation, cardiac arrest

Frequency not reported: Left ventricular failure, flushing

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Tremor

Rare (less than 0.1%): Seizures

Frequency not reported: Coma, encephalopathy, convulsions, paraesthesia, grand mal convulsion

Death, coma, and encephalopathy have been reported as a result of abrupt postoperative reversal of opioid depression, primarily in patients with preexisting cardiovascular disorders or in those who received other drugs with similar adverse cardiovascular effects.


Very rare (less than 0.01%): Pulmonary edema

Frequency not reported: Dyspnea, respiratory depression, hypoxia, nasal dryness, nasal edema, nasal congestion, nasal inflammation

It has been suggested that pulmonary edema may be due to a centrally mediated massive catecholamine response leading to a dramatic shift of blood volume into the pulmonary vascular bed resulting in increased hydrostatic pressures.

Nasal dryness, nasal edema, nasal congestion, and nasal inflammation were the most common adverse reactions reported in clinical trials with naloxone nasal spray.


Frequency not reported: Nonspecific injection site reactions, irritation of vessel was after IV administration


Common (1% to 10%): Nausea, vomiting

Uncommon (0.1% to 1%): Diarrhea, dry mouth


Very rare (less than 0.01%): Erythema multiforme

Frequency not reported: Sweating


Very rare (less than 0.01%): Allergic reactions including urticaria, rhinitis, dyspnea, Quincke's edema, anaphylactic shock


Frequency not reported: Agitation, hallucination, tremulousness


Musculoskeletal pain was one of the more commonly reported adverse reactions in clinical trials with naloxone (the active ingredient contained in Evzio) nasal spray.

Frequency not reported: Musculoskeletal pain

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Evzio