Note: This document contains side effect information about bupivacaine liposome. Some of the dosage forms listed on this page may not apply to the brand name Exparel.
Applies to bupivacaine liposome: injection suspension
Along with its needed effects, bupivacaine liposome (the active ingredient contained in Exparel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking bupivacaine liposome:
Incidence not known
Some side effects of bupivacaine liposome may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to bupivacaine liposome: injectable suspension
The most common adverse reactions reported when administration was via infiltration were nausea, vomiting, and dizziness; when administration was via nerve block, common adverse reactions have included nausea, pyrexia, and constipation.
Convulsions have been reported following accidental intravascular injection of this drug and other amide-containing products.
Very common (10% or more): Dizziness (up to 11.3%), motor dysfunction (14.9%)
Common (1% to 10%): Headache, somnolence, hypoesthesia, syncope, dysgeusia, sensory loss
Frequency not reported: Tremor, dizziness postural, paresthesia, syncope, tinnitus, sedation, somnolence, convulsions
Very common (10% or more): Nausea (up to 40.2%), vomiting (up to 27.8%), constipation (up to 22%)
Common (1% to 10%): Anal hemorrhage, painful defecation, rectal discharge, hypoesthesia oral
Frequency not reported: Procedural nausea
Very common (10% or more): Pruritus (up to 15%)
Common (1% to 10%): Pruritus generalized, hyperhidrosis,
Frequency not reported: Erythema, rash pruritic, cold sweat, urticaria, cellulitis, wound dehiscence, wound secretion, blister, drug eruption, erythema, rash, hematoma
Common (1% to 10%): Insomnia, confusional state
Frequency not reported: Anxiety, depression, agitation, restlessness
Common (1% to 10%): Hypotension, tachycardia, sinus tachycardia, bradycardia, peripheral edema, hypertension
Frequency not reported: Bradycardia, procedural hypertension, procedural hypotension, palpitations, sinus bradycardia, supraventricular extrasystoles, ventricular extrasystoles, ventricular tachycardia, blood pressure increased, blood pressure decreased, pallor, arrhythmia, atrial fibrillation, atrioventricular block first degree, bundle branch block left, bundle branch block right, cardiac arrest, deep vein thrombosis, orthostatic hypotension, electrocardiogram QT prolonged, presyncope, syncope
Cardiac arrest has been reported following accidental intravascular injection of this drug and other amide-containing products.
Rare (less than 0.1%): Allergic-type reactions
Very common (10% or more): Pyrexia (up to 23.3%)
Common (1% to 10%): Procedural pain, lethargy, body temperature increased, feeling hot, post-procedural swelling, fatigue, fall
Frequency not reported: Chills, pain, edema, hearing impaired, asthenia
Common (1% to 10%): Anemia, anemia postoperative, hemorrhagic anemia, postprocedural hematoma
Frequency not reported: White blood cell count increased
Common (1% to 10%): Alanine aminotransferase increased, aspartate aminotransferase increased, increased hepatic enzyme
Common (1% to 10%): Muscle spasms, back pain, muscle twitching
Frequency not reported: Muscular weakness, neck pain, arthralgia, back pain, joint swelling, mobility decreased, muscle spasms, muscular weakness, musculoskeletal pain
Common (1% to 10%): Fungal infection
Common (1% to 10%): Appetite decreased
Frequency not reported: Oxygen saturation decreased, hypokalemia
Common (1% to 10%): Blood creatinine increased
Common (1% to 10%): Hiccups, hypoxia
Frequency not reported: Laryngospasm, apnea, respiratory depression, respiratory failure, lung infection, pneumonia, cough, dyspnea, lung infiltration, atelectasis
Frequency not reported: Urinary retention, urinary incontinence, dysuria
Frequency not reported: Incision site edema
Frequency not reported: Vision blurred, visual impairment
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Exparel