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Generic Name: ferumoxytol (FER ue MOX i tol)
Brand Names: Feraheme
Feraheme is used to treat iron deficiency anemia. Learn about side effects, interactions and indications.
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Drug Information:
Feraheme (ferumoxytol) is a type of iron. You normally get iron from the foods you eat. In your body, iron becomes a part of your hemoglobin (HEEM o glo bin) and myoglobin (MY o glo bin). Hemoglobin carries oxygen through your blood to tissues and organs. Myoglobin helps your muscle cells store oxygen. Feraheme is used to treat iron deficiency anemia (a lack of red blood cells caused by having too little iron in the body). Feraheme injection is used in people with chronic kidney disease, or in people unable to take oral iron (by mouth) or who have not responded well to oral iron Learn more

Feraheme Side Effects

Feraheme Side Effects

Note: This document contains side effect information about ferumoxytol. Some of the dosage forms listed on this page may not apply to the brand name Feraheme.

For the Consumer

Applies to ferumoxytol: intravenous solution


Intravenous route (Solution)

Risk For Serious Hypersensitivity/Anaphylaxis ReactionsFatal and serious hypersensitivity reactions, including anaphylaxis, have occurred in patients receiving ferumoxytol. Initial symptoms may include hypotension, syncope, unresponsiveness, and cardiac or cardiorespiratory arrest.Only administer ferumoxytol as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions.Observe for signs or symptoms of hypersensitivity reactions during and for at least 30 minutes following ferumoxytol infusion including monitoring of blood pressure and pulse during and after ferumoxytol administration.Hypersensitivity reactions have occurred in patients in whom a previous ferumoxytol dose was tolerated.

Along with its needed effects, ferumoxytol (the active ingredient contained in Feraheme) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ferumoxytol:

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision
  • chest pain
  • confusion
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever
  • rapid weight gain
  • sweating
  • tightness in the chest
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss

Incidence not known

  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • chest discomfort
  • cough
  • decreased urine output
  • difficulty with swallowing
  • dilated neck veins
  • dizziness
  • extreme tiredness or weakness
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • hives, itching, or skin rash
  • irregular breathing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of consciousness
  • nausea
  • no blood pressure or pulse
  • pain in the shoulders, arms, jaw, or neck
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • stopping of the heart
  • unconsciousness
  • unresponsiveness
  • vomiting
  • weight gain

Some side effects of ferumoxytol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Back pain
  • headache
  • muscle spasms
  • stomach pain

For Healthcare Professionals

Applies to ferumoxytol: intravenous solution


The most common adverse events were injection site reactions, gastrointestinal symptoms, headache, dizziness, and hypotension.


Common (1% to 10%): Injection site reactions (infusion/injection site bruising, pain, reaction, swelling, warmth, hemorrhage, irritation, rash)


Common (1% to 10%): Nausea, vomiting, abdominal pain (abdominal distension, abdominal pain upper, abdominal discomfort)

Uncommon (0.1% to 1%): Diarrhea, constipation, feces discolored

Rare (less than 0.1%): Dry mouth, dyspepsia, glossodynia

Frequency not reported: Lip swelling, swollen tongue


Common (1% to 10%): Hypotension (hypotension, blood pressure decreased)

Uncommon (0.1% to 1%): Flushing (flushing, hot flush), hypertension (hypertension, accelerated hypertension)

Rare (less than 0.1%): Cardiac arrest, cardio-respiratory arrest, myocardial events, congestive heart failure

Frequency not reported: Tachycardia/arrhythmia, myocardial infarction, vasodilation, pulse absent

Postmarketing reports: Cyanosis

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Dysgeusia, somnolence, burning sensation

Rare (less than 0.1%): Paresthesia

Frequency not reported: Syncope, unresponsiveness, loss of consciousness


Common (1% to 10%): Pruritus (pruritus generalized), rash (rash, rash generalized, rash pruritic, urticaria)

Uncommon (0.1% to 1%): Ecchymosis, sweating (hyperhidrosis, night sweats), skin hyperpigmentation, skin reaction

Frequency not reported: Angioedema


Common (1% to 10%): Cough, dyspnea

Rare (less than 0.1%): Epistaxis

Frequency not reported: Bronchospasm, hyperventilation, hypoxia, laryngeal edema, pharyngeal edema, respiratory arrest, respiratory failure, throat irritation, throat tightness, wheezing


Common (1% to 10%): Back pain, muscle spasms

Uncommon (0.1% to 1%): Muscle/joint pain or stiffness (arthralgia, myalgia, muscular weakness, musculoskeletal stiffness)


Common (1% to 10%): Edema

Uncommon (0.1% to 1%): Decreased appetite, increased appetite

Rare (less than 0.1%): Dehydration, gout, hyperkalemia, blood glucose decreased

Frequency not reported: Oxygen saturation decreased


Uncommon (0.1% to 1%): Hypersensitivity (including anaphylaxis)

Postmarketing reports: Life-threatening anaphylactic/anaphylactoid reactions


Rare (less than 0.1%): Eosinophilia


Rare (less than 0.1%): Hepatic function abnormal


Common (1% to 10%): Peripheral edema, chest pain (chest discomfort, chest pain), fever (feeling hot, pyrexia)

Uncommon (0.1% to 1%): Fatigue (asthenia, fatigue), chills, serum ferritin increased, contusion


Rare (less than 0.1%): Lacrimation increased, vision blurred


Frequency not reported: Chronic renal failure

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Feraheme