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Generic Name: amantadine (a MAN ta deen)
Brand Names: Gocovri
Gocovri (amantadine) is used to control sudden uncontrolled movements in patients with Parkinson's disease. Includes Gocovri side effects, interactions and indications.
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Drug Information:
Gocovri is a prescription medicine containing amantadine. Gocovri extended release capsules are used to treat dyskinesia (sudden uncontrolled movements) in people with Parkinson's disease who are treated with levodopa or levodopa plus other medicines that increase the effects of dopamine in the brain. Gocovri may also be used for purposes not listed in this medication guide. You should not use Gocovri if you received a nasal flu vaccine in the past 14 days. Do not receive a nasal flu vaccine while taking Gocovri, and for at least 48 hours after your last dose. Learn more

Gocovri Side Effects

Gocovri Side Effects

Note: This document contains side effect information about amantadine. Some of the dosage forms listed on this page may not apply to the brand name Gocovri.

For the Consumer

Applies to amantadine: oral capsule, oral capsule extended release, oral capsule liquid filled, oral syrup, oral tablet, oral tablet extended release

Along with its needed effects, amantadine (the active ingredient contained in Gocovri) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amantadine:

More common

  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • confusion
  • difficult, burning, or painful urination
  • dizziness or lightheadedness
  • fainting
  • falls
  • frequent urge to urinate
  • lower back or side pain
  • seeing, hearing, or feeling things that are not there
  • swelling of the hands, feet, or lower legs

Less common

  • Inability to move the eyes
  • increased blinking or spasms of the eyelid
  • muscle spasm
  • sticking out of the tongue
  • troubled breathing, speaking, or swallowing
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unusual facial expressions


  • Chills
  • decreased vision or any change in vision
  • difficulty in coordination
  • fever
  • increased blood pressure
  • increase in body movements
  • irritation and swelling of the eye
  • loss of memory
  • mental depression
  • seizures
  • severe mood or mental changes
  • skin rash
  • slurred speech
  • sore throat
  • thoughts of suicide or attempts at suicide

Some side effects of amantadine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Agitation
  • anxiety
  • difficulty concentrating
  • headache
  • irritability
  • loss of appetite
  • nausea
  • nervousness
  • nightmares
  • purplish red, net-like, or blotchy spots on the skin
  • trouble with sleeping

Less common

  • Constipation
  • decrease in sexual desire
  • diarrhea
  • drowsiness
  • dryness of the mouth, nose, and throat
  • false sense of well-being
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to amantadine: compounding powder, oral capsule, oral capsule extended release, oral syrup, oral tablet, oral tablet extended release


The more commonly reported adverse reactions have included nausea, dizziness/lightheadedness, and insomnia.

Nervous system

Common (1% to 10%): Dizziness/lightheadedness, ataxia, headache, somnolence, dystonia

Uncommon (0.1% to 1%): Weakness, slurred speech, hyperkinesia

Rare (less than 0.1%): Convulsion

Frequency not reported: Falling asleep during activities of daily living, withdrawal-emergent hyperpyrexia (a syndrome resembling neuroleptic malignant syndrome)

Postmarketing reports: Coma, delirium, hypokinesia, involuntary muscle contractions, gait abnormalities, paresthesia, EEG changes, tremor


Very common (10% or more): Hallucinations (up to 21%)

Common (1% to 10%): Insomnia, depression, anxiety, irritability, hallucinations, confusion, nervousness, abnormal dreams, agitation

Uncommon (0.1% to 1%): Psychosis, euphoria, abnormal thinking, amnesia

Rare (less than 0.1%): Suicide attempt, suicide, suicidal ideation

Postmarketing reports: Stupor, delusions, aggressive behavior, paranoid reaction, manic reaction, pathological gambling, increased libido including hypersexuality, and impulse control symptoms


Very common (10% or more): Dry mouth (up to 16%); constipation (up to 13%)

Common (1% to 10%): Nausea, anorexia, diarrhea, decreased appetite

Uncommon (0.1% to 1%): Vomiting

Postmarketing reports: Dysphagia


Very common (10% or more): Peripheral edema (up to 16%), orthostatic hypotension (up to 13%)

Uncommon (0.1% to 1%): Congestive heart failure, hypertension

Postmarketing reports: Cardiac arrest, arrhythmias including malignant arrhythmias, hypotension, and tachycardia


Common (1% to 10%): Dry eye, cataract, blurred vision

Uncommon (0.1% to 1%): Visual disturbance, punctate subeithelial or other corneal opacity, corneal edema, decreased visual acuity, sensitivity to light, optic nerve palsy

Rare (less than 0.1%): Oculogyric episodes

Postmarketing reports: Keratitis, mydriasis


Very common (10% or more): Fall (up to 13%)

Common (1% to 10%): Fatigue, contusions

Frequency not reported: Death

Postmarketing reports: Fever

Deaths have been reported from overdose with the lowest reported acute lethal dose as 1 gram. Drug overdose has resulted in cardiac, respiratory, renal, or CNS toxicity. Deaths have been reported in patients with renal impairment and attributed to drug accumulation.


Common (1% to 10%): Dry nose, cough

Uncommon (0.1% to 1%): Dyspnea

Postmarketing reports: Acute respiratory failure, pulmonary edema, tachypnea


Rare (less than 0.1%): Leukopenia, neutropenia

Postmarketing reports: Leukocytosis, agranulocytosis


Common (1% to 10%): Livedo reticularis, pigmentation disorder

Uncommon (0.1% to 1%): Skin rash

Rare (less than 0.1%): Eczematoid dermatitis

Postmarketing reports: Pruritus, diaphoresis


Postmarketing reports: Allergic reactions including anaphylactic reactions


Common (1% to 10%): Urinary tract infection, benign prostatic hyperplasia

Uncommon (0.1% to 1%): Urinary retention, decreased libido


Postmarketing reports: Elevated: CPK, BUN, serum creatinine


Rare (less than 0.1%): Reversible liver enzyme elevations

Postmarketing reports: Elevated: alkaline phosphatase, LDH, bilirubin, GGT, SGOT, and SGPT


Common (1% to 10%): Joint swelling, muscle spasms

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Gocovri