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Generic Name: hyaluronidase (injection) (HYE al ure ON i dase)
Brand Names: Amphadase, Hylenex, Vitrase
Hylenex is a genitically designed protein used as an aid in helping your body absorb other injected medications. Learn about side effects, interactions and indications.
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Drug Information:
Hylenex (hyaluronidase) is a genetically designed protein. Hylenex is used together with fluids injected into the body to treat dehydration. Hyaluronidase can also be used as an aid in helping your body absorb other injected medications. Hylenex is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans. Serious drug interactions can occur when certain medicines are used together with Hylenex. Tell your doctor about all your current medicines. Before receiving Hylenex, tell your doctor if you are using any of the following drugs: furosemide (Lasix); phenytoin (Dilantin); a sedative or anxiety medication (such as Valium, Xanax, Tranxene); aspirin or salicylates; cortisone or ACTH (Corticotropin); estrogens; or an antihistamine (such as a cold or allergy medicine). Learn more

Hylenex Side Effects

Hylenex Side Effects

Note: This document contains side effect information about hyaluronidase. Some of the dosage forms listed on this page may not apply to the brand name Hylenex.

For the Consumer

Applies to hyaluronidase: solution

Along with its needed effects, hyaluronidase (the active ingredient contained in Hylenex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hyaluronidase:


  • Cough
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • hives or welts
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking hyaluronidase:

Symptoms of overdose

  • Blurred vision
  • chills
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • nausea or vomiting
  • redness of the skin
  • sweating
  • swelling
  • unusual tiredness or weakness
  • unusually warm skin

Some side effects of hyaluronidase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to hyaluronidase: injectable powder for injection, injectable solution


Rare (less than 0.1%): Allergic reactions (e.g. urticaria, angioedema), anaphylactic-like reactions following retrobulbar block or intravenous injection


Postmarketing reports: Local injection site reactions


Postmarketing reports: Enhancement of adverse events of co-administered drugs; edema (reported most frequently in association with hypodermoclysis)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Hylenex