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Jetrea (ocriplasmin) is used to treat symptomatic vitreomacular adhesion (VMA). Includes Jetrea side effects, interactions and indications.
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Drug Information:
The U.S. Food and Drug Administration (FDA) has approved Jetrea (ocriplasmin) for the treatment of symptomatic vitreomacular adhesion, a progressive sight threatening condition. Jetrea is the first pharmacological agent to be approved for this indication. The approval was based on the data from ThromboGenics’ Phase III program where Jetrea was shown to be superior to placebo for the treatment of symptomatic VMA (26.5% versus 10.1%; p<0.01). Treatment with Jetrea was associated with some, mainly transient, ocular adverse events. The most common side effects reported in patients treated with Jetrea include eye floaters; bleeding of the conjunctiva, the tissue that lines the inside of the eyelids and covers the white part of the eye; eye pain; flashes of light (photopsia); blurred vision; unclear vision; vision loss; retinal edema (swelling); and macular edema. Learn more

Jetrea Side Effects

Jetrea Side Effects

Note: This document contains side effect information about ocriplasmin ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Jetrea.

In Summary

More frequent side effects include: decreased visual acuity and intraocular inflammation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ocriplasmin ophthalmic: intraocular solution

Along with its needed effects, ocriplasmin ophthalmic (the active ingredient contained in Jetrea) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ocriplasmin ophthalmic:

More common

  • Bloody eyes
  • blurred vision or other change in vision
  • decreased vision
  • eye pain
  • redness of the eye
  • seeing flashes or sparks of light
  • sensitivity of the eye to light
  • tearing

Less common

  • Change in color vision
  • difficulty seeing at night
  • eye discomfort
  • loss of vision
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
  • throbbing pain

Some side effects of ocriplasmin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Dry eyes

For Healthcare Professionals

Applies to ocriplasmin ophthalmic: intravitreal solution


The most commonly reported side effects included vitreous floaters, eye pain, photopsia, and blurred vision.


Very common (10% or more): Vitreous floaters (up to 16.8%), eye pain (up to 13.1%), photopsia (up to 11.8%)

Common (1% to 10%): Abnormal color vision test/abnormal Roth 28-hue color vision test, abnormal macular reflex, abnormal optical coherence tomography (OCT), abnormal retinogram, anterior chamber cell, anterior chamber flare, blurred vision, chromatopsia, conjunctival edema, conjunctival hemorrhage, conjunctival hyperemia, cystoid macular edema, decrease in a-/b-wave amplitude, decreased vision, dim vision, dry eye, dyschromatopsia, electroretinographic (ERG) changes, eye irritation, eye pruritus, eyelid edema, foreign body sensation in eye, incomplete inner segment/outer segment (IS/OS) band, increased intraocular pressure, increased lacrimation, intraocular hemorrhage, intraocular inflammation, iritis, macular degeneration, macular edema, macular hole (new onset/worsening), metamorphopsia, ocular discomfort, ocular hyperemia, photophobia, reduced visual acuity, retinal breaks/detachment/tears, retinal degeneration, retinal edema, retinal hemorrhage, retinal pigment epitheliopathy, subretinal fluid, visual field defect, visual impairment, vitreomacular adhesion/vitreomacular traction worsening, vitreous adhesions, vitreous detachment, vitreous hemorrhage, vitreitis, yellowish vision

Uncommon (0.1% to 1%): Anterior chamber inflammation, conjunctival irritation, corneal abrasion, diplopia, eye inflammation, hyphema, impaired pupillary reflex, lens subluxation, longer-term reduced visual acuity, miosis, night blindness, serious/severe acute visual impairment, transient blindness, unequal pupils

Frequency not reported: Cataract, visual symptoms perceived in the contralateral eye

Nervous system

Common (1% to 10%): Scotoma


Frequency not reported: Immunogenicity


Common (1% to 10%): Intravitreal injection procedure associated effects

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Jetrea