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Generic Name: cemiplimab-rwlc (se MIP li mab)
Brand Names: Libtayo
Libtayo (cemiplimab-rwlc) is used to treat metastatic cutaneous squamous cell carcinoma. Includes Libtayo side effects, interactions and indications.
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Drug Information:
Libtayo (cemiplimab-rwlc) is a medicine used to treat skin cancer by working with your immune system. Libtayo is used to treat a certain type of skin cancer called cutaneous squamous cell carcinoma (CSCC) that has spread to other parts of the body or cannot be treated with radiation or surgery. Libtayo can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. These problems may happen anytime during treatment or even after your treatment has ended. Learn more

Libtayo Side Effects

Libtayo Side Effects

Note: This document contains side effect information about cemiplimab. Some of the dosage forms listed on this page may not apply to the brand name Libtayo.

For the Consumer

Applies to cemiplimab: intravenous solution

Along with its needed effects, cemiplimab (the active ingredient contained in Libtayo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cemiplimab:

More common

  • Chills
  • cough
  • diarrhea
  • fever
  • hoarseness
  • itching, skin rash
  • lower back or side pain
  • painful or difficult urination

Less common

  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • chest pain or discomfort
  • confusion
  • dark urine
  • dizziness
  • fainting
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • general tiredness and weakness
  • headache
  • light-colored stools
  • lightheadedness
  • muscle or bone pain
  • muscle weakness
  • nausea
  • nervousness
  • pain, redness, swelling, tenderness, or warmth on the skin
  • pale skin
  • pounding in the ears
  • rapid, shallow breathing
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • stiff neck or back
  • thickening of bronchial secretions
  • tightness in the chest
  • trouble breathing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal pain
  • vomiting
  • yellow eyes and skin

Some side effects of cemiplimab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation
  • decreased appetite

For Healthcare Professionals

Applies to cemiplimab: intravenous solution


Uncommon (0.1% to 1%): Uveitis, iritis, retinal detachment, visual impairment, blindness


Uncommon (0.1% to 1%): Myocarditis, pericarditis, vasculitides


Very common (10% or more): Rash (e.g., maculopapular rash, dermatitis, generalized rash, dermatitis bullous, drug eruption, erythema, erythematous rash, macular rash, pruritic rash, skin reaction) (25%), pruritus (15%)


Common (1% to 10%): Hypothyroidism, hyperthyroidism

Uncommon (0.1% to 1%): Adrenal insufficiency, hypophysitis


Very common (10% or more): Diarrhea/colitis (22%), nausea (19%), constipation (12%)

Uncommon (0.1% to 1%): Colitis, pancreatitis


Common (1% to 10%): Immunogenicity


Uncommon (0.1% to 1%): Infusion-related reactions


Very common (10% or more): Decreased appetite (10%)

Uncommon (0.1% to 1%): Type 1 diabetes mellitus, myositis, rhabdomyolysis, arthritis, polymyalgia rheumatica


Very common (10% or more): Musculoskeletal (e.g., back pain, myalgia, neck pain, pain in extremity (17%)

Nervous system

Uncommon (0.1% to 1%): %): Meningitis, encephalitis, myelitis and demyelination, myasthenic syndrome/myasthenia gravis, Guillain-Barre syndrome, nerve paresis, autoimmune neuropathy


Uncommon (0.1% to 1%): Nephritis, renal failure


Common (1% to 10%): Pneumonitis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Libtayo