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Generic Name: atropine and diphenoxylate (A troe peen and DYE fen OX i late)
Brand Name: Lomotil
Physician reviewed Lomotil patient information - includes Lomotil description, dosage and directions.
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Drug Information:
Atropine affects the body in many different ways, such as reducing spasms in the bladder, stomach, and intestines. Diphenoxylate is an antidiarrheal medication. Lomotil is a combination medicine used to treat diarrhea in adults and children who are at least 13 years old. Lomotil may also be used for purposes not listed in this medication guide. Do not use Lomotil if you have diarrhea that is caused by bacteria or by taking an antibiotic. You should not use Lomotil if you have a bile duct disorder causing jaundice (yellowing of your skin or eyes). Learn more

Lomotil Side Effects

Lomotil Side Effects

Note: This document contains side effect information about atropine / diphenoxylate. Some of the dosage forms listed on this page may not apply to the brand name Lomotil.

For the Consumer

Applies to atropine / diphenoxylate: oral solution, oral tablet

Along with its needed effects, atropine/diphenoxylate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking atropine/diphenoxylate:

Incidence not known

  • Bloating
  • confusion
  • constipation
  • cough
  • decrease in the frequency of urination
  • decrease in urine volume
  • diarrhea
  • difficulty in passing urine (dribbling)
  • difficulty swallowing
  • discouragement
  • dizziness
  • drowsiness
  • dry skin and mouth
  • extremely high fever or body temperature
  • false or unusual sense of well-being
  • fast, shallow breathing
  • fast, weak heartbeat
  • feeling of warmth
  • feeling sad or empty
  • headache
  • hives, itching, skin rash
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • muscle cramps
  • nausea
  • numbness of the arms and legs
  • painful urination
  • pale, clammy skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the face, neck, arms and occasionally, upper chest
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • stomach cramps or pain
  • thirst
  • tightness in the chest
  • trouble concentrating
  • trouble sleeping
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • unusual tiredness or weakness
  • vomiting
  • weight loss

Get emergency help immediately if any of the following symptoms of overdose occur while taking atropine / diphenoxylate:

Symptoms of overdose

  • Agitation
  • back pain
  • bigger, dilated, or enlarged pupils (black part of eye)
  • blurred vision
  • difficult or troubled breathing
  • feeling of warmth
  • fever
  • garbled speech
  • increased sensitivity of the eyes to light
  • irregular, fast or slow, or shallow breathing
  • loss of consciousness
  • mood or mental changes
  • pale or blue lips, fingernails, or skin
  • seizures
  • speech that is not understood
  • stiff neck
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to atropine / diphenoxylate: oral liquid, oral tablet

Nervous system

Frequency not reported: Numbness of extremities, sedation/drowsiness, dizziness, headache, somnolence


Frequency not reported: Swelling of the gums, toxic megacolon, paralytic ileus, pancreatitis, vomiting, nausea, abdominal discomfort, constipation


Frequency not reported: Tachycardia, cardiac irregularities (e.g. arrhythmias, bradycardia, palpitations)


Frequency not reported: Increased intraocular pressure, dilation of pupils with loss of accommodation, photophobia, angle closure glaucoma


Frequency not reported: Urinary retention, difficulty in micturition


Frequency not reported: Euphoria, depression, confusion, restlessness, hallucinations


Frequency not reported: Urticaria, pruritus, flushing


Frequency not reported: Anaphylaxis, angioneurotic edema


Frequency not reported: Anorexia


Frequency not reported: Respiratory depression in children


Frequency not reported: Malaise/lethargy, hyperthermia, dryness of the skin and mucous membranes

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Lomotil