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Generic Name: Hydrochlorothiazide and Triamterene (hye droe klor oh THYE a zide & trye AM ter een)
Brand Name: Dyazide, Maxzide, Maxzide-25
Easy-to-read patient leaflet for Maxzide-25. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This is not a list of all drugs or health problems that interact with Maxzide-25 (hydrochlorothiazide and triamterene). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Maxzide-25 (hydrochlorothiazide and triamterene) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Maxzide-25 (hydrochlorothiazide and triamterene) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

Maxzide-25 Side Effects

Maxzide-25 Side Effects

Note: This document contains side effect information about hydrochlorothiazide / triamterene. Some of the dosage forms listed on this page may not apply to the brand name Maxzide-25.

For the Consumer

Applies to hydrochlorothiazide / triamterene: oral capsule, oral tablet


Oral route (Capsule)

Abnormal elevation of serum potassium levels (greater than or equal to 5.5 mEq/L (5.5 mmol/L)) can occur. Risk of hyperkalemia is increased in patients with renal impairment, diabetes (with or without renal impairment), the elderly, or severely ill. Serum potassium levels must be monitored at frequent intervals, especially in hydrochlorothiazide/triamterene-naive patients, when dosages are changed, or with any illness that may influence renal function

Along with its needed effects, hydrochlorothiazide / triamterene may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / triamterene:

Incidence not known

  • Abdominal or stomach pain
  • agitation
  • back or leg pains
  • black, tarry stools
  • bleeding gums
  • blisters, hives, or itching
  • bloating
  • blood in the urine or stools
  • blue lips and fingernails
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • clay-colored stools
  • cloudy urine
  • cold sweats
  • coma
  • confusion
  • constipation
  • convulsions
  • cough or hoarseness
  • coughing that sometimes produces a pink frothy sputum
  • dark urine
  • decreased urine output
  • depression
  • difficult, fast, noisy breathing, sometimes with wheezing
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting position
  • drowsiness
  • dry mouth
  • fast, slow, or irregular heartbeat
  • fever with or without chills
  • flushed, dry skin
  • fruit-like breath odor
  • general body swelling
  • general feeling of discomfort, illness, or weakness
  • greatly decreased frequency of urination or amount of urine
  • headache
  • hostility
  • incoherent speech
  • increased hunger
  • increased sweating
  • increased thirst
  • increased urination
  • indigestion
  • irritability
  • joint pain, stiffness, or swelling
  • lethargy
  • loss of appetite
  • loss of consciousness
  • lower back or side pain
  • metallic taste
  • mood changes
  • muscle pain, cramps, weakness, or twitching
  • nausea or vomiting
  • nervousness
  • nosebleeds
  • numbness or tingling in the hands, feet, or lips
  • pain in the groin or genitals
  • painful or difficult urination
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • pinpoint red or purple spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • seizures
  • sharp back pain just below the ribs
  • shortness of breath
  • skin rash
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomachache
  • stupor
  • sugar in the urine
  • swelling of the face, ankles, hands, feet, or lower legs
  • swollen or painful glands
  • thickening of bronchial secretions
  • tightness in the chest
  • troubled breathing
  • unexplained weight loss
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • weak pulse
  • weakness or heaviness of the legs
  • wheezing
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking hydrochlorothiazide / triamterene:

Symptoms of overdose

  • Face is warm or hot to touch
  • frequent urination
  • increased volume of pale, dilute urine
  • loss of strength or energy
  • pain or weakness in the hands or feet
  • redness to face
  • reflexes are unusually strong
  • trembling

Some side effects of hydrochlorothiazide / triamterene may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Decreased interest in sexual intercourse
  • feeling of constant movement of self or surroundings
  • inability to have or keep an erection
  • increased sensitivity of the skin to sunlight
  • loss in sexual ability, desire, drive, or performance
  • redness or other discoloration of the skin
  • sensation of spinning
  • severe sunburn
  • welts

For Healthcare Professionals

Applies to hydrochlorothiazide / triamterene: oral capsule, oral tablet


Frequency not reported: Diabetes mellitus, hyperkalemia, hyperglycemia, hyperuricemia, hypokalemia, hyponatremia, acidosis, hypochloremia, thirst, minor serum electrolyte changes, marked fluctuations in serum potassium levels


Frequency not reported: Pancreatitis, nausea, vomiting, diarrhea, constipation, abdominal pain, dry mouth, sialadenitis


Frequency not reported: Acute renal failure, interstitial nephritis, renal stones composed primarily of triamterene, BUN elevated, serum creatinine elevated

There is no evidence that stone formation is increased in patients taking triamterene containing drugs.


Frequency not reported: Rash, urticaria, photosensitivity, purpura


Frequency not reported: Arrhythmias, postural hypotension, undesirable decrease in blood pressure


Frequency not reported: Glycosuria, abnormal urinary sediment, impotence


Frequency not reported: Leukopenia, thrombocytopenia, megaloblastic anemia


Frequency not reported: Thrombocytopenic purpura, megaloblastic anemia


Frequency not reported: Jaundice, liver enzyme abnormalities


Frequency not reported: Muscle cramps, systemic lupus erythematosus

Nervous system

Frequency not reported: Dizziness, headache


Frequency not reported: Weakness, fatigue


Frequency not reported: Anaphylaxis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Maxzide-25