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Generic Name: pyridostigmine (py rid o STIG meen)
Brand Name: Mestinon, Mestinon Timespan
Physician reviewed Mestinon patient information - includes Mestinon description, dosage and directions.
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Drug Information:
Mestinon affects chemicals in the body that are involved in the communication between nerve impulses and muscle movement. Mestinon is used to treat the symptoms of myasthenia gravis. It is also used in military personnel who have been exposed to nerve gas. Mestinon may also be used for purposes not listed in this medication guide. You should not use Mestinon if you you have a bladder or bowel obstruction. You should not use Mestinon if you are allergic to it, or if you have a bladder or bowel obstruction. Learn more

Mestinon Side Effects

Mestinon Side Effects

Note: This document contains side effect information about pyridostigmine. Some of the dosage forms listed on this page may not apply to the brand name Mestinon.

For the Consumer

Applies to pyridostigmine: oral conventional 30-mg tablets for military use, oral conventional 60-mg tablets and extended-release tablets, oral oral solution, parenteral injection


    Military Use for Soman Poisoning Prophylaxis
  • Use of pyridostigmine alone is not protective against soman effects. Efficacy depends on rapid use of nerve agent antidotes (i.e., atropine and pralidoxime) following nerve agent exposure.

  • Protective garments (e.g., masks, hoods, overgarments) specifically designed for protection from chemical nerve agents are the primary means of protection against nerve agent exposure; do not rely solely on pretreatment with pyridostigmine, atropine, and pralidoxime to provide complete protection.

  • Do not administer pyridostigmine after soman exposure. Discontinue at first sign of nerve agent poisoning; may exacerbate effects of a sublethal exposure.

    Experience of Health Care Personnel
  • Pyridostigmine should be administered by IV injection only by adequately trained individuals familiar with the drug’s actions, characteristics, and risks.

Side effects include:

Diarrhea, abdominal pain or cramps, dysmenorrhea, increased flatus, nausea, urinary urgency and frequency.

For Healthcare Professionals

Applies to pyridostigmine: injectable solution, oral syrup, oral tablet, oral tablet extended release


Frequency not reported: Nausea, vomiting, diarrhea, abdominal cramps, GI hypermotility, salivary hypersecretion


Frequency not reported: Increased bronchial secretion combined with bronchoconstriction


Frequency not reported: Muscle weakness, fasciculation, tremors, muscle cramps, muscle hypotonia


Frequency not reported: Miosis, increased lacrimation, accommodation disorders


Frequency not reported: Rash, hyperhidrosis


Frequency not reported: Arrhythmia (including bradycardia, tachycardia, AV block), syncope, hypotension


Frequency not reported: Urinary urgency

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Mestinon