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Generic Name: mitomycin (MYE toe MYE sin)
Brand Name: Mutamycin
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Drug Information:
Mutamycin is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Mutamycin is used in combination with other cancer medications to treat cancer of the stomach and pancreas. Mutamycin treats only the symptoms of stomach or pancreatic cancer but does not treat the cancer itself. Mutamycin may also be used for purposes not listed in this medication guide. Mutamycin can weaken (suppress) your immune system, and you may get an infection more easily. Call your doctor if you have signs of infection (fever, weakness, cold or flu symptoms, skin sores, frequent or recurring illness). Learn more

Mutamycin Side Effects

Mutamycin Side Effects

Note: This document contains side effect information about mitomycin. Some of the dosage forms listed on this page may not apply to the brand name Mutamycin.

For the Consumer

Applies to mitomycin: intravenous powder for solution


Intravenous route (Powder for Solution)

Bone marrow suppression, notably thrombocytopenia and leukopenia, which may contribute to overwhelming infections in an already compromised patient, is the most common and severe of the toxic effects of mitomycin injection. Hemolytic Uremic Syndrome (HUS) has been reported in patients receiving systemic mitomycin. The syndrome may occur at any time during therapy with mitomycin, but most cases occur at doses greater than or equal to 60 mg. Blood product transfusion may exacerbate the symptoms associated with this syndrome.

Along with its needed effects, mitomycin (the active ingredient contained in Mutamycin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way cancer medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur while taking mitomycin:

Less common

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • unusual bleeding or bruising


  • Redness or pain, especially at place of injection

Check with your doctor as soon as possible if any of the following side effects occur while taking mitomycin:

Less common

  • Cough
  • decreased urination
  • shortness of breath
  • sores in mouth and on lips
  • swelling of feet or lower legs


  • Bloody vomit

Some side effects of mitomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Loss of appetite
  • nausea and vomiting

Less common

  • Numbness or tingling in fingers and toes
  • purple-colored bands on nails
  • skin rash
  • unusual tiredness or weakness

Mitomycin sometimes causes a temporary loss of hair. After treatment has ended, normal hair growth should return.

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Blood in urine

Also, check with your doctor if you notice any of the following:

  • Black, tarry stools
  • blood in stools
  • cough or hoarseness
  • decreased urination
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • red or painful skin
  • shortness of breath
  • swelling of feet or lower legs
  • unusual bleeding or bruising

For Healthcare Professionals

Applies to mitomycin: compounding powder, intravenous powder for injection


Very common (10% or more): Bone marrow toxicity (64%), thrombocytopenia, leucopenia, pancytopenia, neutropenia, granulocytopenia, erythropenia, microangiopathic hemolytic anemia, myelodysplastic syndrome, thrombotic thrombocytopenic purpura


Very common (10% or more): Fever (14%)

Frequency not reported: Fatigue, edema, pain


Common (1% to 10%): Allergic skin rash, contact dermatitis, palmar-plantar erythema, pruritus, exanthema, integument and mucous membrane toxicity

Uncommon (0.1% to 1%): Alopecia


Common (1% to 10%): Interstitial pneumonia, dyspnea, cough, shortness of breath

Rare (less than 0.1%): Pulmonary hypertension, pulmonary veno-occlusive disease (PVOD)


Common (1% to 10%): Renal dysfunction, increase in serum creatinine, glomerulopathy, nephrotoxicity

Rare (less than 0.1%): Hemolytic uremic syndrome (HUS) (commonly fatal), microangiopathic-hemolytic anemia (MAHA syndrome)


Rare (less than 0.1%): Heart failure (after previous therapy with anthracyclines)


Very common (10% or more): Anorexia (14%), nausea (14%), vomiting (14%)

Uncommon (0.1% to 1%): Mucositis, stomatitis, diarrhea


Common (1% to 10%): Cystitis (possibly hemorrhagic), dysuria, nocturia, pollakiuria, hematuria, local irritation of the bladder wall

Very rare (less than 0.01%): Necrotizing cystitis, allergic (eosinophilic) cystitis, stenosis of the efferent urinary tract, reduced bladder capacity, bladder wall calcification, bladder wall fibrosis, bladder perforation

Frequency not reported: Increased frequency of micturition, rash and pruritus on hands and genital area

Postmarketing reports: Bladder fibrosis/contraction rarely requiring cystectomy


Very rare (less than 0.01%): Severe allergic reaction


Rare (0.01% to 0.1%): Life-threatening infection (e.g., bacterial, viral, fungal), sepsis, hemolytic anemia

Frequency not reported: Septic shock


Common (1% to 10%): Following extravasation: Cellulitis, tissue necrosis


Frequency not reported: Blurred vision


Frequency not reported: Confusion


Rare (less than 0.1%): Liver dysfunction, increased transaminases, jaundice, veno-occlusive disease (VOD)


Frequency not reported: Myelodysplastic syndrome, acute myeloid leukemia, acute leukemia

Nervous system

Frequency not reported: Headache, drowsiness, syncope

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Mutamycin