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Generic Name: parathyroid hormone (PAR a THY roid HOR mone)
Brand Names: Natpara
Natpara (parathyroid hormone) is used to treat hypocalcemia in patients with hypoparathyroidism. Includes Natpara side effects, interactions and indications.
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Drug Information:
Natpara (parathyroid hormone) is a manmade form of a hormone that occurs naturally in the body. Natpara is used together with calcium and vitamin D to treat hypocalcemia (low levels of calcium in the blood) in people who also have low levels of parathyroid hormone. Natpara is usually given after calcium and vitamin D alone have been tried without success. Natpara is available only under a special program. You must be registered in the program and understand the risks and benefits of this medicine. Learn more

Natpara Side Effects

Natpara Side Effects

Note: This document contains side effect information about parathyroid hormone. Some of the dosage forms listed on this page may not apply to the brand name Natpara.

In Summary

Common side effects of Natpara include: decreased serum calcium, diarrhea, hypercalcemia, increased serum calcium, increased urine calcium excretion, vomiting, and hypocalcemia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to parathyroid hormone: subcutaneous powder for solution


Subcutaneous route (Powder for Solution)

In male and female rats, parathyroid hormone caused an increase in the incidence of osteosarcoma (a malignant bone tumor). The occurrence of osteosarcoma was dependent on parathyroid hormone dose and treatment duration. This effect was observed at parathyroid hormone exposure levels ranging from 3 to 71 times the exposure levels in humans receiving a 100 mcg dose of parathyroid hormone. These data could not exclude a risk to humans.Because of a potential risk of osteosarcoma, use parathyroid hormone only in patients who cannot be well-controlled on calcium and active forms of vitamin D alone and for whom the potential benefits are considered to outweigh this potential risk.Avoid use of parathyroid hormone in patients who are at increased baseline risk for osteosarcoma, such as patients with Paget’s disease of bone or unexplained elevations of alkaline phosphatase, pediatric and young adult patients with open epiphyses, patients with hereditary disorders predisposing to osteosarcoma or patients with a prior history of external beam or implant radiation therapy involving the skeleton.Because of the risk of osteosarcoma, parathyroid hormone is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the NATPARA REMS Program.

Along with its needed effects, parathyroid hormone (the active ingredient contained in Natpara) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking parathyroid hormone:

More common

  • Abdominal or stomach cramps or pain
  • blurred vision
  • confusion
  • constipation
  • convulsions
  • depression
  • difficulty with breathing
  • dizziness
  • dry mouth
  • headache
  • incoherent speech
  • increased urination
  • irregular heartbeats
  • loss of appetite
  • metallic taste
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle weakness
  • nausea
  • nervousness
  • numbness and tingling around the mouth, fingertips, or feet
  • pounding in the ears
  • slow or fast heartbeat
  • thirst
  • tremor
  • unusual tiredness
  • vomiting
  • weight loss

Some side effects of parathyroid hormone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abnormal or decreased touch sensation
  • body aches or pain
  • chills
  • cough
  • diarrhea
  • difficulty with moving
  • ear congestion
  • fever
  • loss of voice
  • muscle pain or stiffness
  • pain in the joints or neck
  • pain or tenderness around the eyes and cheekbones
  • sneezing
  • sore throat
  • stuffy or runny nose
  • tightness of the chest
  • upper abdominal or stomach pain

For Healthcare Professionals

Applies to parathyroid hormone: subcutaneous powder for injection


The more commonly reported adverse reactions have included paresthesia, hypocalcemia, headache, hypercalcemia, nausea, hypoesthesia, diarrhea, vomiting, arthralgia, hypercalciuria, and extremity pain.


Very common (10% or more): Hypocalcemia (27%), hypercalcemia (19%); hypercalciuria (11%)

Hypocalcemia combines reported events of hypocalcemia and blood calcium decreased; hypercalciuria combines reported events of hypercalciuria and urine calcium increased; and hypercalcemia combines reported events of hypercalcemia and blood calcium increased.

During clinical trials, 3 patients receiving this drug required IV fluids to correct hypercalcemia. In the postmarketing period, seizures due to hypocalcemia have been reported. The risk of hypocalcemia increases when this drug is withdrawn.

Nervous system

Very common (10% or more): Paresthesia (31%), headache (25%), hypoesthesia (14%)

Common (1% to 10%): Facial hypoesthesia

Postmarketing reports: Seizures due to hypocalcemia


Postmarketing reports: Hypersensitivity reactions including anaphylaxis, dyspnea, angioedema, urticaria, rash


Common (1% to 10%): Hypertension


Very common (10% or more): Nausea (18%), diarrhea (12%), vomiting (12%)

Common (1% to 10%): Upper abdominal pain


Very common (10% or more): Arthralgia (11%), pain in extremity (10%)

Common (1% to 10%): Neck pain


Common (1% to 10%): Immunogenicity


Common (1% to 10%): Blood 25-hydroxycholecalciferol decreased


Common (1% to 10%): Upper respiratory tract infection, sinusitis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Natpara