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Generic Name: human chorionic gonadotropin (HCG) (injectable) (HUE man KORE ee ON ik goe NAD oh TRO pin)
Brand Name: Novarel, Ovidrel, Pregnyl
Physician reviewed Ovidrel (injectable) (injectable) patient information - includes Ovidrel (injectable) description, dosage and directions.
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Drug Information:
Ovidrel is a hormone that supports the normal development of an egg in a woman's ovary, and stimulates the release of the egg during ovulation. HCG is used to cause ovulation and to treat infertility in women, and to increase sperm count in men. HCG is also used in young boys when their testicles have not dropped down into the scrotum normally. This can be caused by a pituitary gland disorder. HCG may also be used for other purposes not listed in this medication guide. Ovidrel is given as an injection under the skin or into a muscle. If you use Ovidrel at home, your doctor, nurse, or pharmacist will give you specific instructions on how and where to inject this medicine. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Learn more

Ovidrel Side Effects

Ovidrel Side Effects

Note: This document contains side effect information about chorionic gonadotropin (hcg). Some of the dosage forms listed on this page may not apply to the brand name Ovidrel.

For the Consumer

Applies to chorionic gonadotropin (hcg): powder for solution, solution

Along with its needed effects, chorionic gonadotropin (hcg) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking chorionic gonadotropin (hcg):

For females only

More common

  • Bloating (mild)
  • stomach or pelvic pain

Less common or rare

  • Abdominal or stomach pain (severe)
  • bloating (moderate to severe)
  • decreased amount of urine
  • feeling of indigestion
  • nausea, vomiting, or diarrhea (continuing or severe)
  • pelvic pain (severe)
  • shortness of breath
  • swelling of feet or lower legs
  • weight gain (rapid)

For boys only

Less common

  • Acne
  • enlargement of penis and testes
  • growth of pubic hair
  • increase in height (rapid)

Frequency not determined

  • difficult or labored breathing
  • difficulty breathing
  • flushing of skin
  • hives or welts
  • itching of skin
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
  • pain in chest, groin, or legs, especially the calves
  • redness of skin
  • severe, sudden headache
  • skin rash
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in arm or leg
  • sudden, unexplained shortness of breath
  • tightness in chest
  • unusually warm skin
  • vision changes
  • wheezing

Some side effects of chorionic gonadotropin (hcg) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Discouragement
  • enlargement of breasts
  • feeling sad or empty
  • headache
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • pain at place of injection
  • trouble concentrating
  • trouble sleeping
  • tiredness

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

For females only

Less common or rare

  • Abdominal or stomach pain (severe)
  • bloating (moderate to severe)
  • decreased amount of urine
  • feeling of indigestion
  • nausea, vomiting, or diarrhea (continuing or severe)
  • pelvic pain (severe)
  • shortness of breath
  • weight gain (rapid)

For Healthcare Professionals

Applies to chorionic gonadotropin (hcg): injectable powder for injection, intramuscular powder for injection, subcutaneous powder for injection, subcutaneous solution


HCG: The most commonly reported side effects included rash, groin pain, loin pain, and fever.

r-HCG: The most commonly reported side effects included injection site pain, headache not otherwise specified (NOS), nausea, and application site disorders.



Frequency not reported: injection site pain, injection site rash, localized hypersensitivity reaction


Very common (10% or more): Injection site pain (up to 19.5%), application site disorder (up to 14.6%)

Common (1% to 10%): Injection site bruising, injection site inflammation, injection site reaction, vessel site hemorrhage

Nervous system


Frequency not reported: Headache


Very common (10% or more): Headache NOS (up to 18%)

Common (1% to 10%): Headache

Frequency not reported: Dizziness, hypesthesia, paresthesia, twitching



Rare (0.01% to 0.1%: Fever

Frequency not reported: Fatigue, pain, swelling, tiredness


Very common (10% or more): Post-operative pain (up to 15.7%)

Common (1% to 10%): Pain, pyrexia, rigors, tiredness

Frequency not reported: Body pain, chromosomal abnormality (47, XXX), congenital anomaly of the fetus/newborn, Down's syndrome, fever, major congenital malformations, malaise, missed abortion, placenta previa, premature birth, premature labor, spontaneous abortion



Frequency not reported: Abdominal discomfort, abdominal pain, acute abdominal pain, ascites, bloating, diarrhea, gastrointestinal symptoms, nausea


Very common (10% or more): Nausea (up to 14.6%), abdominal pain (up to 11.2%)

Common (1% to 10%): Abdominal pain lower, mouth ulceration, vomiting

Uncommon (0.1% to 1%): Diarrhea

Frequency not reported: Abdominal enlargement, flatulence, hemoperitoneum



Frequency not reported: Large ovarian cysts (prone to rupture), mild ovarian hyperstimulation syndrome (OHSS), mild to moderate enlargement of ovaries, ovarian cysts, painful breasts, severe OHSS, unwanted ovarian hyperstimulation


Common (1% to 10%): Dysmenorrhea, intermenstrual bleeding, ovarian cyst, ovarian hyperstimulation, mild/moderate OHSS

Uncommon (0.1% to 1%): Breast pain, severe OHSS

Frequency not reported: Adnexal torsion, albuminuria, cervical lesion, dysuria, ectopic pregnancy, genital herpes, genital moniliasis, leukorrhea, mild to moderate ovarian enlargement, ovarian enlargement, ovarian torsion, postpartum fever, urinary incontinence, urinary tract infection, uterine disorders, vaginal discomfort, vaginal hemorrhage, vaginitis



Frequency not reported: Dyspnea, hydrothorax, shortness of breath


Common (1% to 10%): Pharyngolaryngeal pain, rhinorrhea, upper respiratory tract infections NOS

Frequency not reported: Acute pulmonary distress, cough, hiccup, pharyngitis, pulmonary complications, upper respiratory tract infection



Common (1% to 10%): Rash

Rare (0.01% to 0.1%): Generalized rash

Frequency not reported: Acne, erythema/redness, itching, urticaria


Common (1% to 10%): Ecchymosis

Very rare (less than 0.01%): Mild reversible skin reactions, rash

Frequency not reported: Pruritus



Common (1% to 10%): Groin pain, loin pain

Frequency not reported: Back pain, cranial malformation



Frequency not reported: Depression, irritability, mood changes, restlessness


Common (1% to 10%): Emotional disturbance NOS

Uncommon (0.1% to 1%): Depression, irritability, restlessness

Frequency not reported: Emotional lability, insomnia


Human Chorionic Gonadotropin (HCG):

Frequency not reported: Bruising, edema, thromboembolism

Recombinant Chorionic Gonadotropin (r-HCG):

Common (1% to 10%): Peripheral swelling

Very rare (less than 0.01%): Shock, thromboembolism

Frequency not reported: Atrial septal defect, cardiac arrhythmia, heart murmur, hot flashes, vascular complications

Postmarketing reports: Thromboembolic events



Common (1% to 10%): Pyelonephritis NOS



Frequency not reported: Allergic reactions, angioedema, systemic hypersensitivity reactions


Very rare (less than 0.01%): Anaphylactic reactions, mild to severe hypersensitivity reactions

Postmarketing reports: Allergic reactions, mild systemic allergic reactions



Frequency not reported: Sodium retention, water retention, weight gain


Frequency not reported: Hyperglycemia



Frequency not reported: Excessive androgen production, gynecomastia, precocious puberty



Frequency not reported: Benign/malignant ovarian neoplasms, cervical carcinoma



Frequency not reported: Leukocytosis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Ovidrel