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Generic Name: peginterferon beta-1a (peg in ter FEAR on BAY ta - 1A)
Brand Names: Plegridy
Plegridy (peginterferon beta-1a) is used to treat multiple sclerosis. Includes Plegridy side effects, interactions and indications.
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Drug Information:
Plegridy (peginterferon beta-1a) is made from human proteins. Interferons stimulate the body's immune responses to infection or disease. Plegridy is used to treat relapsing multiple sclerosis (MS) in adults who are 18 to 65 years old. Plegridy will not cure multiple sclerosis, it will only decrease the frequency of relapse symptoms. Plegridy can cause serious side effects, including: Call your healthcare provider right away if you have any of the symptoms listed above. You should not use Plegridy if you are allergic to peginterferon beta-1a. Learn more

Plegridy Side Effects

Plegridy Side Effects

Note: This document contains side effect information about peginterferon beta-1a. Some of the dosage forms listed on this page may not apply to the brand name Plegridy.

In Summary

Common side effects of Plegridy include: arthralgia, asthenia, fever, flu-like symptoms, headache, myalgia, chills, erythema at injection site, pain at injection site, and swelling at injection site. Other side effects include: suicidal ideation, hyperthermia, increased serum alanine aminotransferase, pruritus, vomiting, decreased white blood cell count, depression, increased serum aspartate aminotransferase, and increased body temperature. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to peginterferon beta-1a: subcutaneous solution

Along with its needed effects, peginterferon beta-1a (the active ingredient contained in Plegridy) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking peginterferon beta-1a:

More common

  • Blue-green to black skin discoloration
  • chills
  • cough or sore throat
  • diarrhea
  • dizziness
  • extremely high fever or body temperature
  • fast, shallow breathing
  • fast, weak heartbeat
  • fever
  • general feeling of discomfort or illness
  • joint pain
  • muscle aches and pains
  • muscle cramps
  • pale, clammy skin
  • runny nose
  • shivering
  • sweating
  • thirst
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

Less common

  • Dark urine
  • decreased appetite
  • general feeling of tiredness or weakness
  • itching skin
  • light-colored stools
  • stomach or abdominal pain
  • yellow eyes or skin


  • Difficulty with swallowing
  • hives or welts
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • skin rash
  • tightness in the chest

Some side effects of peginterferon beta-1a may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty with moving
  • itching, rash, redness, soreness, swelling, or warmth at the injection site
  • lack or loss of strength
  • muscle stiffness
  • pain, redness, or sloughing of skin at the injection site

For Healthcare Professionals

Applies to peginterferon beta-1a: subcutaneous kit, subcutaneous solution


Frequency not reported: Congestive heart failure


Common (1% to 10%): Pruritus


Common (1% to 10%): Nausea, vomiting


The most common side effects were injection site erythema, influenza-like illness, pyrexia, headache, myalgia, chills, injection site pain, asthenia, injection site pruritus, and arthralgia.


Frequency not reported: Decreased peripheral blood counts


Common (1% to 10%): Alanine aminotransferase increased, aspartate aminotransferase increased, gamma-glutamyl-transferase increased

Frequency not reported: hepatic injury


Uncommon (0.1% to 1%): Anaphylaxis, angioedema, urticaria


Very common (10% or more): Influenza like illness (47%)

Frequency not reported: Autoimmune disorders


Very common (10% or more): Injection site erythema (62%), injection site pain (15%), injection site pruritus (13%)

Common (1% to 10%): Injection site edema, injection site warmth, injection site hematoma, injection site rash


Very common (10% or more): Myalgia (19%), arthralgia (11%)

Nervous system

Very common (10% or more): Headache (44%)

Uncommon (0.1% to 1%): Seizures


Very common (10% or more): Pyrexia (45%), chills (17%), asthenia (13%)

Common (1% to 10%): Hyperthermia, pain


Common (1% to 10%): Depression, suicide

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Plegridy