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Generic Name: rifapentine (RIF a PEN teen)
Brand Name: Priftin
Physician reviewed Priftin patient information - includes Priftin description, dosage and directions.
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Drug Information:
Priftin is an antibiotic that fights bacteria. Priftin is used together with other medicines to treat active tuberculosis (TB) in adults and children who are at least 12 years old. Priftin is also used to keep inactive (latent) TB from becoming active in adults and children who are at least 2 years old. Priftin must always be used in combination with other tuberculosis medications. Priftin may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Learn more

Priftin Side Effects

Priftin Side Effects

Note: This document contains side effect information about rifapentine. Some of the dosage forms listed on this page may not apply to the brand name Priftin.

In Summary

More frequent side effects include: diarrhea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to rifapentine: oral tablet

Along with its needed effects, rifapentine (the active ingredient contained in Priftin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rifapentine:

More common

  • Blood in the urine
  • joint pain
  • lower back or side pain
  • swelling of the feet or lower legs

Less common

  • Aggressive reaction
  • black, tarry stools
  • blood in the stools
  • nausea
  • pinpoint red spots on the skin
  • severe abdominal or stomach pain
  • sore throat and fever
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin


  • Diarrhea
  • dizziness
  • increase in blood pressure
  • severe or continuing headaches

Some side effects of rifapentine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Acne
  • constipation
  • loss of appetite

For Healthcare Professionals

Applies to rifapentine: oral tablet


The most commonly reported side effects included anemia, lymphopenia, hemoptysis, and neutropenia.


Very common (10% or more): Anemia (up to 11.4%), lymphopenia (up to 10.5%)

Common (1% to 10%): Leukocytosis, lymphadenopathy, neutropenia, thrombocytopenia, thrombocytosis

Frequency not reported: Leukopenia, lymphocytosis


Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, nausea, vomiting

Frequency not reported: Clostridium difficile-associated diarrhea, constipation, dry mouth, esophageal irritation, esophagitis, gastritis, pancreatitis, salivary gland enlargement


Common (1% to 10%): Maculopapular rash, pruritus, rash, sweating increased

Uncommon (0.1% to 1%): Skin reaction

Frequency not reported: Facial edema, hyperhidrosis, itching, purpura, skin discoloration, sweats, urticaria


Common (1% to 10%): ALT increased, AST increased, hepatotoxicity

Uncommon (0.1% to 1%): Hepatitis

Frequency not reported: Alkaline phosphatase increased, bilirubinemia, hepatomegaly, jaundice


Common (1% to 10%): Coughing/cough, hemoptysis

Frequency not reported: Acute bronchospasm, asthma, bronchial hyperactivity, bronchospasm, dysphonia, dyspnea, epistaxis, laryngeal edema, laryngitis, oropharyngeal pain, pharyngitis, pneumonitis, pulmonary fibrosis, shortness of breath

Nervous system

Common (1% to 10%): Dizziness, headache

Frequency not reported: Convulsion, paresthesia, peripheral neuropathy, somnolence, syncope


Common (1% to 10%): Arthralgia, back pain

Frequency not reported: Arthritis, muscle pain, myalgia, myositis, rhabdomyolysis


Common (1% to 10%): Hypersensitivity/hypersensitivity reaction

Frequency not reported: Anaphylaxis, angioedema


Common (1% to 10%): Fever

Frequency not reported: Abortion, aches, asthenia, body fluid discoloration, chills, death, fatigue, feeling jittery, pyrexia, weakness


Common (1% to 10%): Anorexia

Frequency not reported: Decreased appetite, gout, hyperglycemia, hyperkalemia, hyperlipidemia, hyperuricemia, porphyria


Common (1% to 10%): Nonprotein nitrogen increased

Frequency not reported: Azotemia, blood urea nitrogen (BUN) increased


Common (1% to 10%): Conjunctivitis


Frequency not reported: Chest pain, flushing, hematoma, hypotension, orthostatic hypotension, palpitation, pericarditis, tachycardia, thrombosis


Frequency not reported: Anxiety, confusion, depression, disorientation, suicidal ideation


Frequency not reported: Hematuria, leukorrhea, vaginal hemorrhage, vaginitis, vulvovaginal candidiasis, vulvovaginal pruritus


Frequency not reported: Flu-like syndrome, fungal infection, viral infection

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Priftin