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Prostin e2

Generic Name: dinoprostone topical (DYE no PROS tone TOP ik al)
Brand Name: Cervidil, Prepidil, Prostin E2
Physician reviewed Prostin E2 patient information - includes Prostin E2 description, dosage and directions.
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Drug Information:
Dinoprostone is a prostaglandin, a hormone-like substance that is naturally produced by tissues in the body. Prostin E2 is used in a pregnant woman to relax the muscles of the cervix (opening of the uterus) in preparation for inducing labor at the end of a pregnancy. Prostin E2 may be used for purposes not listed in this medication guide. You should not be treated with Prostin E2 if you are allergic to prostaglandins, or if you have active genital herpes with a vaginal lesion, placenta previa, or if your water has broken. Learn more

Prostin e2 Side Effects

Prostin E2 Side Effects

Note: This document contains side effect information about dinoprostone topical. Some of the dosage forms listed on this page may not apply to the brand name Prostin E2.

For the Consumer

Applies to dinoprostone topical: vaginal gel/jelly, vaginal insert extended release, vaginal suppository


Vaginal route (Suppository)

Dinoprostone should be used with strict adherence to recommended dosages and only by medically trained personnel in a hospital setting that can provide immediate intensive care and acute surgical facilities.

Along with its needed effects, dinoprostone topical (the active ingredient contained in Prostin E2) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dinoprostone topical:

Less common or rare

  • Fast or slow heartbeat
  • hives
  • increased pain of the uterus
  • pale, cool, blotchy skin on arms or legs
  • pressing or painful feeling in chest
  • shortness of breath
  • swelling of face, inside the nose, and eyelids
  • tightness in chest
  • trouble in breathing
  • weak or absent pulse in arms or legs
  • wheezing

Some side effects of dinoprostone topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach cramps
  • diarrhea
  • fever
  • nausea
  • vomiting

Less common or rare

  • Chills or shivering
  • constipation
  • flushing
  • headache
  • swelling of the genital area (vulva)
  • tender or mildly bloated abdomen or stomach

This procedure may still result in some effects, which occur after the procedure is completed, that need medical attention. Check with your doctor if any of the following side effects occur while taking dinoprostone topical:

  • Chills or shivering (continuing)
  • fever (continuing)
  • foul-smelling vaginal discharge
  • pain in lower abdomen
  • unusual increase in bleeding of the uterus

For Healthcare Professionals

Applies to dinoprostone topical: vaginal gel, vaginal insert, vaginal suppository


Uncommon (0.1% to 1%): Nausea, vomiting, diarrhea, abdominal pain


Very common (10% or more): Any fetal heart rate abnormality

Frequency not reported: Hearing impairment, neonatal distress, neonatal death, stillbirths, low Apgar score


Common (1% to 10%): Hypotension, bradycardia

Frequency not reported: Flushing or hot flashes, chest pain, cardiac arrhythmia

Nervous system

Uncommon (0.1% to 1%): Fever

Frequency not reported: Headache, dizziness, weakness, tremor, paresthesia


Rare (0.01% to 0.1%): Postpartum disseminated intravascular coagulation

Frequency not reported: Elevated WBC


Frequency not reported: Dehydration


Frequency not reported: Back pain, joint inflammation or pain new or exacerbated, muscle cramp or pain, nocturnal leg cramps


Frequency not reported: Dyspnea, coughing, pharyngitis, laryngitis, wheezing, tightness in chest, pharyngitis, laryngitis


Frequency not reported: Rash, diaphoresis, skin discoloration


Frequency not reported: Blurred vision, eye pain


Frequency not reported: Anaphylactic reactions (including anaphylactic shock)


Common (1% to 10%): Uterine hyperstimulation (with or without fetal distress), fetal distress without uterine hyperstimulation, warm feeling in vagina

Frequency not reported: Uterine hypertonus, uterine rupture, placenta abruptio, rapid cervical dilatation, vaginal pain, vaginal irritation, vaginitis or vulvitis, breast tenderness, vaginismus, genital edema, transient vasovagal symptoms (flushing, shivering, headache, dizziness)


Frequency not reported: Tension

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Prostin E2