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Generic Name: silodosin (SIL oh DOE sin)
Brand Names: Rapaflo
Rapaflo (silodosin) is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate). Includes Rapaflo side effects, interactions and indications.
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Drug Information:
Rapaflo (silodosin) is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blocker. Rapaflo helps relax the muscles in the prostate and bladder neck, making it easier to urinate. Rapaflo is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate). You should not take Rapaflo if you have severe kidney or liver disease. Do not take silodosin together with similar medicines such as alfuzosin, doxazosin, prazosin, tamsulosin, or terazosin. Rapaflo may cause dizziness or fainting, especially when you first start taking it. Be careful if you drive or do anything that requires you to be alert. Avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Learn more

Rapaflo Side Effects

Rapaflo Side Effects

Note: This document contains side effect information about silodosin. Some of the dosage forms listed on this page may not apply to the brand name Rapaflo.

In Summary

Common side effects of Rapaflo include: retrograde ejaculation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to silodosin: oral capsule

Along with its needed effects, silodosin (the active ingredient contained in Rapaflo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking silodosin:

Less common

  • Chills
  • cold sweats
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

Incidence not known

  • Abdominal or stomach pain
  • clay-colored stools
  • dark urine
  • fever
  • headache
  • itching
  • loss of appetite
  • nausea
  • pinpoint red or purple spots on the skin
  • rash
  • skin blisters
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Some side effects of silodosin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change or problem with discharge of semen

Less common

  • Diarrhea
  • muscle aches
  • sore throat
  • stuffy or runny nose

For Healthcare Professionals

Applies to silodosin: oral capsule


The most common adverse reaction was retrograde ejaculation.


Very common (10% or more): Retrograde ejaculation (28.1%)

Common (1% to 10%): Prostate-specific antigen (PSA) increased

Uncommon (0.1% to 1%): Priapism


Common (1% to 10%): Nasopharyngitis, nasal congestion, sinusitis, rhinorrhea

Postmarketing reports: Pharyngeal edema

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Syncope


Common (1% to 10%): Diarrhea, abdominal pain

Postmarketing reports: Swollen tongue


Common (1% to 10%): Orthostatic hypotension


Common (1% to 10%): Asthenia


Common (1% to 10%): Insomnia


Frequency not reported: Intraoperative floppy iris syndrome


Postmarketing reports: Toxic skin eruption, purpura, skin rash, pruritus, urticaria


Postmarketing reports: Jaundice, hepatic function impaired, transaminases increased


Postmarketing reports: Allergic-type reactions

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Rapaflo