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Generic Name: maraviroc (ma RAV i rok)
Brand Names: Selzentry
Selzentry is used to treat CCR5-tropic human immunodeficiency virus (HIV). Learn about side effects, interactions and indications.
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Drug Information:
Selzentry (maraviroc) is an antiviral medicine that prevents certain viral cells from multiplying in your body. Selzentry is used with other medications to treat CCR5-tropic human immunodeficiency virus (HIV) type 1. HIV causes the acquired immunodeficiency syndrome (AIDS). Selzentry is for use in adults and children who are at least 2 years old. Maraviroc is not a cure for HIV or AIDS. If you have severe kidney disease, you may not be able to take Selzentry if you use certain other medications. Tell your doctor about all other medications you use. Learn more

Selzentry Side Effects

Selzentry Side Effects

Note: This document contains side effect information about maraviroc. Some of the dosage forms listed on this page may not apply to the brand name Selzentry.

In Summary

Common side effects of Selzentry include: upper respiratory tract infection, fever, and skin rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to maraviroc: oral solution, oral tablet


Oral route (Solution; Tablet)

Hepatotoxicity has been reported with use of maraviroc. Severe rash or evidence of a systemic allergic reaction (eg, fever, eosinophilia, or elevated IgE) prior to the development of hepatotoxicity may occur. Patients with signs or symptoms of hepatitis or allergic reaction following use of maraviroc should be evaluated immediately .

Along with its needed effects, maraviroc (the active ingredient contained in Selzentry) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking maraviroc:

More common

  • Body aches or pain
  • burning or stinging of the skin
  • chills
  • cough producing mucus
  • coughing
  • difficulty with breathing
  • dizziness when getting up suddenly from a lying or sitting position
  • ear congestion
  • headache
  • loss of voice
  • pain or tenderness around the eyes and cheekbones
  • painful blisters on the trunk of the body
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • sneezing
  • sore throat
  • stuffy or runny nose
  • tightness of the chest
  • troubled breathing
  • unusual tiredness or weakness

Less common

  • Abdominal or stomach pain or tenderness
  • arm, back, or jaw pain
  • black, tarry stools
  • blood in the urine
  • blurred or double vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • burning, dry, or itching eyes
  • burning, itching, and pain in the hairy areas, pus at the root of the hair
  • change in consciousness
  • chest pain, discomfort, or heaviness
  • choking
  • clay-colored stools
  • cold, clammy skin
  • confusion
  • convulsions
  • dark-colored urine
  • diarrhea
  • dilated neck veins
  • discharge or excessive tearing
  • dizziness
  • drowsiness
  • earache
  • extreme fatigue
  • eye pain
  • fast, weak pulse
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • general feeling of tiredness or weakness
  • heavy jaw feeling
  • inability to speak
  • increased frequency of urination
  • irregular breathing
  • itching or rash
  • joint pain
  • light-colored stools
  • lightheadedness
  • loosening of a tooth
  • loss of appetite
  • loss of bladder control
  • loss of taste
  • lumps in the tongue
  • muscle aches, pains, or stiffness
  • muscle cramps or spasms
  • nausea or vomiting
  • nervousness
  • noisy breathing
  • pain or burning during urination
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, swelling, or numbness in the mouth or jaw
  • pale skin
  • pounding in the ears
  • redness or swelling in the ear
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • sensitivity of the eye to light
  • severe abdominal or stomach cramps and pain
  • severe or sudden headache
  • shakiness in the legs, arms, hands, or feet
  • shivering
  • skin lumps
  • slow, fast, or irregular heartbeat
  • slurred speech
  • spread of cancer to the liver
  • stiff neck or back
  • stomach lumps
  • stomach pain, continuing
  • sudden loss of consciousness
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swollen glands
  • tearing
  • temporary blindness
  • trembling or shaking of the hands or feet
  • trouble sleeping
  • troubled breathing with exertion
  • unable to speak
  • unpleasant breath odor
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • vomiting of blood
  • warts on the genital area
  • watery and severe diarrhea, which may also be bloody
  • weakness in the arms, hands, legs, or feet
  • weakness on one side of the body, sudden and severe
  • weight gain
  • weight loss
  • yellow eyes or skin

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • cough
  • muscle pain
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sores, ulcers, or white spots in the mouth or on the lips

Some side effects of maraviroc may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty having a bowel movement (stool)
  • difficulty with moving
  • increased or decreased appetite
  • swelling or redness in the joints

Less common

  • Acid or sour stomach
  • belching
  • blistering, crusting, irritation, or reddening of the skin
  • canker sores
  • discouragement
  • feeling sad or empty
  • flushing or redness of the skin
  • heartburn
  • indigestion
  • irritability
  • loss of interest or pleasure
  • redistribution or accumulation of body fat
  • skin rash, encrusted, scaly, and oozing
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • stomach discomfort or upset
  • tiredness
  • trouble in concentrating
  • unusually warm skin

For Healthcare Professionals

Applies to maraviroc: oral liquid, oral tablet


The most common side effects reported with twice-daily treatment were cough, pyrexia, upper respiratory tract infections, rash, and dizziness. The most common side effects reported with once-daily dosing were diarrhea, edema, influenza, esophageal candidiasis, sleep disorders, rhinitis, parasomnias, and urinary abnormalities. Nausea, diarrhea, fatigue, and headache were common in Phase 2b/3 trials.


Very common (10% or more): Upper respiratory tract infection (up to 32%), coughing and associated symptoms (14%), bronchitis (up to 13%)

Common (1% to 10%): Upper respiratory tract signs/symptoms, sinusitis, upper respiratory tract signs/symptoms, nasal congestion and inflammations, breathing abnormalities, paranasal sinus disorders, lower respiratory tract and lung infections, pneumonia, influenza

Frequency not reported: Rhinitis, bronchospasm and obstruction, respiratory tract disorders, epistaxis


Very common (10% or more): Pyrexia (13%)

Common (1% to 10%): Asthenia, herpes infection, bacterial infections, herpes zoster/varicella, pain and discomfort, Neisseria infections, viral infections, body temperature perception, ear disorders, otitis media

Frequency not reported: Edema, fatigue, hot flushes, condyloma acuminatum, treponema infections, septic shock


Very common (10% or more): Rash (up to 11%)

Common (1% to 10%): Nail and nail bed conditions (excluding infections and infestations), apocrine and eccrine gland disorders, pruritus, folliculitis, tinea infections, lipodystrophies, acnes, erythemas, alopecias

Frequency not reported: Dermatitis, eczema

Postmarketing reports: Severe skin reactions (including Stevens-Johnson syndrome, drug rash with eosinophilia and systemic symptoms [DRESS], toxic epidermal necrolysis)

Severe, potentially life-threatening skin and hypersensitivity reactions were characterized by rash, constitutional findings, and sometimes organ dysfunction, including hepatic failure. In most cases, other drugs associated with such reactions were coadministered.


Severe, potentially life-threatening skin and hypersensitivity reactions were characterized by rash, constitutional findings, and sometimes organ dysfunction, including hepatic failure. In most cases, other drugs associated with such reactions were coadministered.

Postmarketing reports: Severe hypersensitivity reactions


Elevated amylase (greater than 2 to 5 times upper limit of normal [ULN]: up to 5.7%; greater than 5 times ULN: up to 0.3%) and elevated lipase (greater than 2 to 5 times ULN: 5%; greater than 5 times ULN: 1.3%) have been reported.

Very common (10% or more): Flatulence, bloating, and distention (10%)

Common (1% to 10%): Gastrointestinal atonic and hypomotility disorders, constipation, elevated amylase, elevated lipase, gastrointestinal signs/symptoms, abdominal pain, flatulence, nausea

Uncommon (0.1% to 1%): Esophageal candidiasis

Frequency not reported: Diarrhea, gastrointestinal pain, dyspeptic signs/symptoms, ulceration stomatitis, gingivitis, dry mouth, vomiting, Clostridium difficile colitis

Nervous system

Common (1% to 10%): Dizziness/postural dizziness, paresthesias and dysesthesias, sensory abnormalities, disturbances in consciousness, peripheral neuropathies, memory loss (excluding dementia)

Uncommon (0.1% to 1%): Seizures and seizure disorders/convulsions and epilepsy

Frequency not reported: Headache, sleep disorders, syncope, cerebrovascular accident, tremor (excluding congenital), facial palsy, hemianopia, loss of consciousness, viral meningitis, meningitis, visual field defect


Common (1% to 10%): Anemias, decreased absolute neutrophil count, neutropenias, decreased hemoglobin

Rare (0.01% to 0.1%): Pancytopenia, granulocytopenia

Frequency not reported: Marrow depression, hypoplastic anemia

Decreased absolute neutrophil count (500 to 749/mm3: up to 4.3%; less than 500/mm3: up to 1.4%) and decreased hemoglobin (6.5 to 6.9 g/dL: 0.6%; less than 6.5 g/dL: 2.3%) have been reported.


Common (1% to 10%): Appetite disorders, anorexia

Rare (0.01% to 0.1%): Increased alkaline phosphatase

Frequency not reported: Unintentional weight loss (wasting), hyperlipidemia


Common (1% to 10%): Disturbances in initiating and maintaining sleep/insomnia, depressive disorders/depression, anxiety symptoms

Frequency not reported: Parasomnias, somnolence


Common (1% to 10%): Joint-related signs/symptoms, elevated creatine kinase, muscle pains

Uncommon (0.1% to 1%): Myositis, increased blood creatine phosphokinase

Rare (0.01% to 0.1%): Muscle atrophy

Frequency not reported: Infective myositis, osteonecrosis, rhabdomyolysis

Elevated creatine kinase (greater than 10 to 20 times ULN: 2.8%; greater than 20 times ULN: 1.1%) has been reported.


Elevated total bilirubin (greater than 2 to 5 times ULN: 5%; greater than 5 times ULN: 5.5%), elevated AST (greater than 5 times ULN: up to 4.8%; greater than 10 times ULN: up to 1.7%), and elevated ALT (greater than 5 times ULN: up to 3.9%; greater than 10 times ULN: up to 1%) have been reported.

Common (1% to 10%): Elevated total bilirubin, elevated AST, elevated ALT

Uncommon (0.1% to 1%): Hyperbilirubinemia, elevated GGT

Rare (0.01% to 0.1%): Toxic hepatitis, hepatic failure, hepatic cirrhosis

Very rare (less than 0.01%): Hepatic failure with allergic features

Frequency not reported: Hepatotoxicity (sometimes associated with rash and eosinophilia), cholestatic jaundice, portal vein thrombosis, hypertransaminasemia, jaundice


Common (1% to 10%): Bladder and urethral symptoms, urinary tract signs/symptoms, erection and ejaculation conditions and disorders, anogenital warts

Uncommon (0.1% to 1%): Proteinuria

Frequency not reported: Urinary abnormalities


Common (1% to 10%): Vascular hypertensive disorders

Rare (0.01% to 0.1%): Angina pectoris

Frequency not reported: Postural/orthostatic hypotension, arrhythmia, unstable angina, acute cardiac failure, coronary artery disease, coronary artery occlusion, endocarditis, myocardial infarction, myocardial ischemia


Common (1% to 10%): Skin neoplasms

Rare (0.01% to 0.1%): Malignant bile duct neoplasms/bile duct cancer, diffuse large B-cell lymphoma, Hodgkin's disease, metastases to bone, metastases to liver, metastases to peritoneum, esophageal carcinoma, nasopharyngeal carcinoma/cancer

Frequency not reported: Abdominal neoplasm, anal cancer, anaplastic large cell lymphomas (T- and null-cell types), endocrine neoplasms (malignant and unspecified), basal cell carcinoma, Bowen's disease, cholangiocarcinoma, lymphoma, squamous cell carcinoma, squamous cell carcinoma of skin, tongue neoplasm (unspecified malignant stage)


Common (1% to 10%): Conjunctivitis; ocular infections, inflammations, and associated manifestations

Frequency not reported: Abnormal vision, eye pain


Uncommon (0.1% to 1%): Renal failure


Frequency not reported: Immune reconstitution syndrome, autoimmune disorders in the setting of immune reconstitution (e.g., Graves' disease, polymyositis, Guillain-Barre syndrome)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Selzentry