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Generic Name: Clomiphene (KLOE mi feen)
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Drug Information:
This is not a list of all drugs or health problems that interact with clomiphene. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take clomiphene with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use clomiphene as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

Serophene Side Effects

Clomiphene Side Effects

For the Consumer

Applies to clomiphene: oral tablet

Along with its needed effects, clomiphene may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking clomiphene:

More common

  • Bloating
  • stomach or pelvic pain

Check with your doctor as soon as possible if any of the following side effects occur while taking clomiphene:

Less common or rare

  • Blurred vision
  • decreased or double vision or other vision problems
  • seeing flashes of light
  • sensitivity of eyes to light
  • yellow eyes or skin

Some side effects of clomiphene may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Hot flashes

Less common or rare

  • Breast discomfort
  • dizziness or lightheadedness
  • headache
  • heavy menstrual periods or bleeding between periods
  • mental depression
  • nausea or vomiting
  • nervousness
  • restlessness
  • tiredness
  • trouble in sleeping

For Healthcare Professionals

Applies to clomiphene: compounding powder, oral tablet


At recommended doses, this drug is well tolerated. Most side effects have been mild and transient and disappear promptly after treatment has stopped.


Very common (10% or more): Ovarian enlargement (up to 13.6%), vasomotor flushes (10.4%)

Common (1% to 10%): Abdominal/pelvic discomfort/distention/bloating, breast discomfort, uterine bleeding abnormal, intermenstrual spotting, menorrhagia

Frequency not reported: Urinary frequency increased, urinary volume increased, vaginal dryness

Postmarketing reports: Endometriosis, ovarian hemorrhage, tubal pregnancy, uterine hemorrhage, reduced endometrial thickness, ovarian hemorrhage, tubal pregnancy, uterine hemorrhage, endometrial thickness reduced

Fetal/Neonatal Patients:

-Postmarketing reports: Hypospadias, cloacal exstrophy


Common (1% to 10%): Blurred vision, lights, floaters, waves, unspecified visual complaints, photophobia, diplopia, scotomata, phosphenes

Postmarketing reports: Abnormal accommodation, cataract, eye pain, macular edema, optic neuritis, photopsia, posterior vitreous detachment, retinal hemorrhage, retinal thrombosis, retinal vascular spasm, temporary or prolonged loss of vision

Fetal/Neonatal Patients:

-Postmarketing reports: Eye malformed, lens malformed/cataract


Postmarketing reports: Arrhythmia, chest pain, hypertension, palpitation, phlebitis, tachycardia, thrombophlebitis

Fetal/Neonatal Patients:

-Postmarketing reports: Septal heart defect, muscular ventricular septal defect, patent ductus arteriosus, tetralogy of Fallot, coarctation of aorta


Postmarketing reports: Thyroid disorder

Fetal/Neonatal Patients:

-Postmarketing reports: Dwarfism


Frequency not reported: Ovarian cancer, ovarian tumor

Postmarketing reports: Ovarian cyst, hepatic hemangiosarcoma, liver cell adenoma, hepatocellular carcinoma, fibrocystic disease, breast carcinoma, endometrial carcinoma, astrocytoma, pituitary tumor, prolactinoma, neurofibromatosis, glioblastoma multiforme, brain abscess, ovary (luteoma of pregnancy, dermoid cyst of the ovary, ovarian carcinoma, hydatiform mole, choriocarcinoma, melanoma, myeloma, perianal cysts, renal cell carcinoma, Hodgkin's lymphoma, tongue carcinoma, bladder carcinoma

Fetal/Neonatal Patients:

-Postmarketing reports: Neuroectodermal tumor, thyroid tumor, hepatoblastoma, lymphocytic leukemia

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Dizziness, lightheadedness

Postmarketing reports: Migraine headache, paresthesia, seizure, stroke, syncope

Fetal/Neonatal Patients:

-Postmarketing reports: Neural tube defect, anencephaly, meningomyelocele), microcephaly, hydrocephalus


Frequency not reported: Dermatitis, rash, hair loss/dry hair

Postmarketing reports: Acne, allergic reaction, erythema, erythema multiforme, erythema nodosum, hypertrichosis, pruritus, urticaria


Common (1% to 10%): Nausea, vomiting

Frequency not reported: Acute abdomen, constipation, diarrhea

Postmarketing reports: Pancreatitis

Fetal/Neonatal Patients:

-Postmarketing reports: Cleft lip/palate, imperforate anus, tracheoesophageal fistula, diaphragmatic hernia, omphalocele


Postmarketing reports: Leukocytosis


Postmarketing reports: Increased transaminases, hepatitis


Frequency not reported: Appetite increased, serum desmosterol levels increase

Postmarketing reports: Hypertriglyceridemia


Postmarketing reports: Arthralgia, back pain, myalgia

Fetal/Neonatal Patients:

-Postmarketing reports: Abnormal bone development, skeletal malformations of skull/face/nasal passages/jaw/hand limb/foot/spine/joints


Frequency not reported: Fatigue, vertigo, weight gain, weight loss

Postmarketing reports: Fever, tinnitus, weakness, edema

Fetal/Neonatal Patients:

-Postmarketing reports: Down's syndrome, ear abnormal, deafness


Frequency not reported: Depression, insomnia, nervous tension

Postmarketing reports: Anxiety, irritability, mood changed, psychosis

Fetal/Neonatal Patients:

Postmarketing reports: Intellectual disability


Postmarketing reports: Pulmonary embolism, shortness of breath

Fetal/Neonatal Patients:

-Postmarketing reports: Lung tissue malformation


Fetal/Neonatal Patients:

-Postmarketing reports: Renal agenesis, renal dysgenesis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Serophene