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Generic Name: zoster vaccine (inactivated) (ZOS ter VAX een)
Brand Names: Shingrix
Shingrix is a vaccine used for the prevention of shingles in adults. Includes Shingrix side effects, interactions and indications.
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Drug Information:
Shingrix is a vaccine used for the prevention of herpes zoster. Herpes zoster is caused by the same virus (varicella) that causes chickenpox in children. When this virus becomes active again, it can cause herpes zoster, or shingles. Shingrix helps prevent shingles. Shingrix works by exposing you to a small dose of inactive virus, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body. Shingrix is used to prevent herpes zoster virus (shingles) in people age 50 and older, including people who previously received a live zoster vaccine (Zostavax). Learn more

Shingrix Side Effects

Shingrix Side Effects

Note: This document contains side effect information about zoster vaccine, inactivated. Some of the dosage forms listed on this page may not apply to the brand name Shingrix.

For the Consumer

Applies to zoster vaccine, inactivated: intramuscular suspension

Along with its needed effects, zoster vaccine, inactivated (the active ingredient contained in Shingrix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zoster vaccine, inactivated:


  • Ankle, knee, or great toe joint pain
  • blindness
  • blurred vision
  • decreased vision
  • eye pain
  • fever greater than 39 degree Celsius
  • joint stiffness or swelling
  • lower back or side pain
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin

Some side effects of zoster vaccine, inactivated may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • difficulty in moving
  • fever
  • headache
  • muscle aches, cramps, pains, or stiffness
  • nausea
  • pain, redness, and swelling at the injection site
  • shivering
  • stomach pain
  • unusual tiredness or weakness
  • vomiting

Less common

  • Chills
  • dizziness
  • general feeling of discomfort or illness
  • itching at the injection site

For Healthcare Professionals

Applies to zoster vaccine, inactivated: intramuscular powder for injection


Very common (10% or more): Local pain (88.4%), local redness (38.7%)

Common (1% to 10%): Injection site pruritus


Very common (10% or more): Fatigue (57%), shivering (35.8%), fever (27.8%)

Common (1% to 10%): Malaise

Uncommon (0.1% to 1%): Death

Deaths were reported for 0.8% of patients in the treatment group during the first year after vaccination versus 0.9% of placebo patients. Causes of death were consistent with those generally reported in adult and elderly populations.

Nervous system

Very common (10% or more): Headache (50.6%)

Common (1% to 10%): Dizziness


Very common (10% or more): Gastrointestinal symptoms (24.3%)

Common (1% to 10%): Nausea


Uncommon (0.1% to 1%): Gout (including gouty arthritis)


Rare (less than 0.1%): Optic ischemic neuropathy


Very rare (less than 0.01%): Lymphadenitis


Very common (10% or more): Myalgia (56.9%)

Common (1% to 10%): Chills, arthralgia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Shingrix