Note: This document contains side effect information about tamoxifen. Some of the dosage forms listed on this page may not apply to the brand name Soltamox.
Common side effects of Soltamox include: amenorrhea, fluid retention, hot flash, nausea, vaginal discharge, vaginal hemorrhage, weight loss, and skin changes. Other side effects include: infection, sepsis, alopecia, constipation, cough, diarrhea, edema, increased serum aspartate aminotransferase, infrequent uterine bleeding, menstrual disease, ostealgia, vomiting, and weight gain. See below for a comprehensive list of adverse effects.
Applies to tamoxifen: oral solution, oral tablet
Oral route (Solution)
Serious, life-threatening, and fatal events from use of tamoxifen include uterine malignancies, stroke, and pulmonary embolism. Discuss risks and benefits of tamoxifen with women at high risk for breast cancer and women with ductal carcinoma in situ (DCIS) when considering tamoxifen use to reduce the risk of developing breast cancer. For most patients already diagnosed with breast cancer, the benefits of tamoxifen outweigh its risks.
Oral route (Tablet)
Serious and life-threatening uterine malignancies, stroke, and pulmonary embolism have been associated with tamoxifen use in the risk reduction setting (women with Ductal Carcinoma in Situ (DCIS) and women at high risk for breast cancer). Some of these adverse events were fatal. Health care providers should discuss the potential benefits versus the potential risks of these serious events with women at high risk of breast cancer and women with DCIS considering tamoxifen to reduce their risk of developing breast cancer. The benefits of tamoxifen outweigh its risks in women already diagnosed with breast cancer.
Along with its needed effects, tamoxifen (the active ingredient contained in Soltamox) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tamoxifen:
Incidence not known
Some side effects of tamoxifen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to tamoxifen: compounding powder, oral solution, oral tablet
Very common (10% or more): Amenorrhea (16%), altered menses (13%), vaginal bleeding, vaginal discharge
Common (1% to 10%): Oligomenorrhea, menstrual disorder, ovarian cysts, uterine fibroids, pruritus vulvae, endometrial changes (including hyperplasia and polyps)
Uncommon (0.1% to 1%): Endometrial cancer
Rare (less than 0.1%): Suppression of menstruation in premenopausal women, endometriosis, cystic ovarian swelling, vaginal polyps, uterine sarcoma (mostly malignant mixed Mullerian tumors), tumor flare
Common (1% to 10%): Bone pain, myalgia, leg cramps
Very common (10% or more): Edema
Uncommon (0.1% to 1%): Hypercalcemia (in patients with bone metastases) on initiation of therapy
Common (1% to 10%): Changes in liver enzymes, fatty liver
Uncommon (0.1% to 1%): Cirrhosis of the liver
Rare (less than 0.1%): Cholestasis, hepatitis, hepatic failure, hepatocellular injury, hepatic necrosis
Common (1% to 10%): Anemia
Uncommon (0.1% to 1%): Thrombocytopenia, leukopenia
Rare (less than 0.1%): Neutropenia, agranulocytosis
Common (1% to 10%): Cataracts, retinopathy
Uncommon (0.1% to 1%): Visual disturbances
Rare (less than 0.1%): Corneal changes, optic neuropathy
Common (1% to 10%): Thromboembolic events (including deep vein thrombosis and microvascular thrombosis); risks are increased when used in combination with cytotoxic agents
Common (1% to 10%): Cough, thromboembolic events (including pulmonary embolism); risk is increased when used in combination with cytotoxic agents
Uncommon (0.1% to 1%): Interstitial pneumonitis
Common (1% to 10%): Depression
Very common (10% or more): Fatigue
Common (1% to 10%): Pain
Very common (10% or more): Skin rash
Common (1% to 10%): Alopecia
Rare (0.01% to 0.1%): Angioedema, Stevens-Johnson syndrome, cutaneous vasculitis, bullous pemphigoid, erythema multiforme
Very rare (less than 0.01%): Cutaneous lupus erythematosus
Common (1% to 10%): Ischemic cerebrovascular events, headache, sensory disturbances (including paresthesia and dysgeusia), light-headedness
Very common (10% or more): Nausea
Common (1% to 10%): Vomiting, diarrhea, constipation, abdominal cramps, anorexia
Uncommon (0.1% to 1%): Pancreatitis
Common (1% to 10%): Hypersensitivity reactions
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Soltamox