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Generic Name: silver sulfadiazine topical (SIL ver SUL fa DYE a zeen TOP ik al)
Brand Name: Silvadene, SSD, Thermazene
Physician reviewed SSD patient information - includes SSD description, dosage and directions.
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Drug Information:
Silver sulfadiazine is an antibiotic. It fights bacteria and yeast on the skin. SSD (for the skin) is used to treat or prevent serious infection on areas of skin with second- or third-degree burns. SSD may also be used for purposes not listed in this medication guide. SSD may cause serious medical problems in a newborn if you use SSD during late pregnancy (close to your delivery date). This medicine should also not be used on premature babies or any child younger than 2 months old. You should not use this medicine if you are allergic to silver sulfadiazine. Learn more

Ssd Side Effects

SSD Side Effects

Note: This document contains side effect information about silver sulfadiazine topical. Some of the dosage forms listed on this page may not apply to the brand name SSD.

For the Consumer

Applies to silver sulfadiazine topical: topical cream

Along with its needed effects, silver sulfadiazine topical (the active ingredient contained in SSD) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking silver sulfadiazine topical:

Incidence not known

  • Back, leg, or stomach pains
  • blistering, peeling, or loosening of the skin
  • blue-green to black skin discoloration
  • dark urine
  • fever with or without chills
  • general body swelling
  • increased sensitivity of the skin to sunlight, especially in patients with burns on large areas
  • intense itching of burn wounds
  • light-colored stools
  • lower back or side pain
  • nausea or vomiting
  • pinpoint red spots on the skin
  • red skin lesions, often with a purple center
  • red, swollen skin
  • skin rash
  • sores, ulcers, or white spots in the mouth or on the lips
  • swollen or painful glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Some side effects of silver sulfadiazine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Brownish-gray skin discoloration
  • burning feeling on treated areas

For Healthcare Professionals

Applies to silver sulfadiazine topical: compounding powder, topical cream


Absorption varies depending upon the percent of body surface area being treated and extent of tissue damage; it is possible any adverse reaction associated with sulfonamides may occur.


Common (1% to 10%): Leukopenia

Frequency not reported: Neutrophil count decreased, white blood cell depression, agranulocytosis, aplastic anemia, thrombocytopenia, hemolytic anemia


Common (1% to 10%): Pruritus, application site rash, eczema, contact dermatitis

Rare (less than 0.1%): Argyria

Frequency not reported: Skin necrosis, erythema multiforme, skin discoloration, burning sensation, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis


Very rare (less than 0.01%): Renal failure

Frequency not reported: Interstitial nephritis


Frequency not reported: Hepatitis, hepatocellular necrosis

Nervous system

Frequency not reported: Central nervous system reactions


Frequency not reported: Gastrointestinal reactions

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Ssd