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Generic Name: ivacaftor and tezacaftor (EYE va KAF tor and TEZ a KAF tor)
Brand Names: Symdeko
Symdeko (tezacaftor and ivacaftor) is used to treat cystic fibrosis. Includes Symdeko side effects, interactions and indications.
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Drug Information:
Symdeko contains a combination of ivacaftor and tezacaftor and is used to treat cystic fibrosis in adults and children who are at least 6 years old. Symdeko is for use only in patients with a specific gene mutation related to cystic fibrosis. Before you take Symdeko, you may need a medical test to make sure you have this gene mutation. Before taking Symdeko , tell your doctor if you: are pregnant or plan to become pregnant. It is not known if ivacaftor and tezacaftor will harm your unborn baby. You and your doctor should decide if you will take Symdeko while you are pregnant. Learn more

Symdeko Side Effects

Symdeko Side Effects

Note: This document contains side effect information about ivacaftor / tezacaftor. Some of the dosage forms listed on this page may not apply to the brand name Symdeko.

For the Consumer

Applies to ivacaftor / tezacaftor: oral tablet

Along with its needed effects, ivacaftor / tezacaftor may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ivacaftor / tezacaftor:


  • Nausea
  • severe constipation
  • stomach pain
  • vomiting

Incidence not known

  • Blindness
  • blurred vision
  • dark urine
  • decreased vision
  • light-colored stools
  • loss of appetite
  • yellow skin or eyes

Some side effects of ivacaftor / tezacaftor may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache

Less common

  • Dizziness
  • stuffy nose

For Healthcare Professionals

Applies to ivacaftor / tezacaftor: oral tablet


The most commonly reported side effects have included headache, nasopharyngitis, nausea, sinus congestion, and dizziness.

Nervous system

Very common (10% or more): Headache (14%)

Common (1% to 10%): Dizziness


Frequency not reported: Non-congenital lens opacities


Common (1% to 10%): Sinus congestion


Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Distal intestinal obstruction syndrome


Common (1% to 10%): Transaminase elevations

The incidence of maximum transaminase (ALT or AST) elevations to greater than 8 times the upper limit of normal (8 x ULN), greater than 5 x ULN, or greater than 3 x ULN was similar between drug treated and placebo treated patients (0.2%, 1%, 3.4% versus 0.4%, 1%, 3.4%, respectively). A total of 3 patients in clinical trials permanently discontinued therapy due to elevated transaminases (1 drug treated and 2 on placebo). No drug-treated patient experienced a transaminase elevation greater than 3 x ULN associated with elevated total bilirubin greater than 2 x ULN.

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Symdeko