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Generic Name: hylan G-F 20 (HI lan G F 20)
Brand Names: Synvisc, Synvisc One
Synvisc is an injection used to treat knee pain caused by osteoarthritis. Learn about side effects, interactions and indications.
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Drug Information:
Synvisc (hylan G-F 20) is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints. Synvisc is used to treat knee pain caused by osteoarthritis. Synvisc is usually given after other arthritis medications have been tried without successful treatment of symptoms. You should not receive Synvisc if you have an infection in your knee or in the skin around your knee. Before you receive a Synvisc injection, tell your doctor if you have blood clots or circulation problems in your legs, or an allergy to birds, feathers, or egg products. Learn more

Synvisc Side Effects

Synvisc Side Effects

Note: This document contains side effect information about hylan g-f 20. Some of the dosage forms listed on this page may not apply to the brand name Synvisc.

For the Consumer

Applies to hylan g-f 20: injection solution

Along with its needed effects, hylan g-f 20 (the active ingredient contained in Synvisc) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hylan g-f 20:

More common

  • Difficulty with moving
  • fluid build up around the knee
  • muscle pain or stiffness
  • pain and stiffness in the joints

Less common

  • Bleeding after defecation
  • bluish color
  • changes in skin color
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • pain or aching in the lower legs
  • swelling of the ankles, feet, or legs
  • tenderness
  • uncomfortable swelling around the anus
  • warmth or swelling of the joints


  • Redness in the joints
  • trouble with walking

Incidence not known

  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chills
  • difficulty with breathing
  • feeling of warmth
  • general feeling of discomfort or illness
  • muscle cramps
  • pinpoint red spots on the skin
  • rapid weight gain
  • redness of the face, neck, arms, and occasionally, upper chest
  • shortness of breath
  • tingling of the hands or feet
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss

Some side effects of hylan g-f 20 may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Itching of the skin
  • rash
  • sprain in the lower back


  • Pain at the injection site

Incidence not known

  • Dizziness
  • headache
  • nausea
  • raised red swellings on the skin, lips, tongue, or in the throat

For Healthcare Professionals

Applies to hylan g-f 20: intra-articular solution


Frequency not reported: Rash, itching, hives, itching, face swelling, generalized urticaria


Frequency not reported: Hemorrhoids, nausea, tonsillitis


Frequency not reported: Low back sprain, calf cramps, muscle cramps

Postmarketing reports: Acute inflammation (e.g., joint pain, swelling, effusion, joint warmth and/or stiffness)


Frequency not reported: Tachyarrhythmia, phlebitis with varicosities, flushing

Nervous system

Frequency not reported: Headache, dizziness, chills, paresthesia


Frequency not reported: Respiratory difficulty


Frequency not reported: Synovial eosinophilia


Postmarketing reports: Injection site pain, injection site swelling


Rare (less than 0.1%): Thrombocytopenia


Frequency not reported: Ankle edema, fever, peripheral edema, malaise

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Synvisc