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Generic Name: thioguanine (THYE oh GWA neen)
Brand Name: Tabloid
Physician reviewed Tabloid patient information - includes Tabloid description, dosage and directions.
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Drug Information:
Tabloid is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Tabloid is used to treat certain types of leukemia. This medicine is sometimes given with other cancer medications. Tabloid may also be used for purposes not listed in this medication guide. You should not use Tabloid if you have ever used Tabloid or mercaptopurine and they were not effective in treating your condition. You should not use Tabloid if you are allergic to it, or if you have ever used this medicine or mercaptopurine and they were not effective in treating your condition. Learn more

Tabloid Side Effects

Tabloid Side Effects

Note: This document contains side effect information about thioguanine. Some of the dosage forms listed on this page may not apply to the brand name Tabloid.

For the Consumer

Applies to thioguanine: oral tablet

Along with its needed effects, thioguanine (the active ingredient contained in Tabloid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking thioguanine:

More common

  • Black, tarry stools
  • blood in the urine or stools
  • chills
  • cough
  • fever
  • hoarseness
  • joint pain, stiffness, or swelling
  • lower back, side, or stomach pain
  • painful or difficult urination
  • pinpoint red spots on the skin
  • swelling of the feet or lower legs
  • unusual bleeding or bruising

Incidence not known

  • Bloody, black, or tarry stools
  • decrease in the amount of urine
  • heartburn
  • indigestion
  • nausea
  • noisy, rattling breathing
  • right upper abdominal pain and fullness
  • severe stomach pain, cramping, or burning
  • stomach bloating
  • swelling of the fingers or hands
  • trouble breathing
  • troubled breathing at rest
  • vomiting of material that looks like coffee grounds, severe and continuing
  • weight gain
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking thioguanine:

Symptoms of overdose

  • Blurred vision
  • cloudy urine
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • general feeling of discomfort or illness
  • increased sweating
  • unusual tiredness or weakness
  • vomiting

Some side effects of thioguanine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Loss of appetite
  • swelling or inflammation of the mouth
  • weight loss

For Healthcare Professionals

Applies to thioguanine: oral tablet


Very common (10% or more): Bone marrow failure, splenomegaly, thrombocytopenia

Frequency not reported: Agranulocytosis


Very common (10% or more): Varices esophageal

Common (1% to 10%): Stomatitis, nausea, vomiting, diarrhea, anorexia

Rare (less than 0.1%): Necrotizing colitis, perforation


Very common (10% or more): Veno-occlusive liver disease, hyperbilirubinemia, hepatomegaly, portal hypertension, hepatic enzymes increased, blood alkaline phosphatase increased, gamma glutamyltransferase increased, jaundice, portal fibrosis, nodular regenerative hyperplasia, peliosis hepatitis

Common (1% to 10%): Veno-occlusive liver disease

Rare (less than 0.1%): Hepatic necrosis


Common (1% to 10%): Hyperuricemia, hyperuricosuria, urate nephropathy


Frequency not reported: Photosensitivity


Frequency not reported: Transient treatment-related megaloblastic marrow changes


Very common (10% or more): Weight increased (due to fluid retention and ascites)

Common (1% to 10%): Hyperuricemia


Common (1% to 10%): Urate nephropathy

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Tabloid