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Generic Name: ixekizumab (IX ee KIZ ue mab)
Brand Names: Taltz Autoinjector, Taltz Prefilled Syringe
Taltz (ixekizumab) is used to treat plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. Includes Taltz side effects, interactions and indications.
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Drug Information:
Taltz (ixekizumab) is an immunosuppressant that reduces the effects of a chemical substance in the body that can cause inflammation. Taltz is used to treat moderate to severe plaque psoriasis (raised, silvery flaking of the skin) in adults. Taltz is used to treat adults with active psoriatic arthritis. Taltz is also used to treat adults with active ankylosing spondylitis. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Learn more

Taltz Side Effects

Taltz Side Effects

Note: This document contains side effect information about ixekizumab. Some of the dosage forms listed on this page may not apply to the brand name Taltz.

For the Consumer

Applies to ixekizumab: subcutaneous solution

Along with its needed effects, ixekizumab (the active ingredient contained in Taltz) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ixekizumab:

More common

  • Body aches or pain
  • burning, dry, or itching eyes
  • chills
  • cough
  • difficulty with breathing
  • discharge or excessive tearing
  • ear congestion
  • fever
  • headache
  • hoarseness
  • itching in the genital or other skin areas
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • painful or difficult urination
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • sneezing
  • sore mouth or tongue
  • sore throat
  • unusual tiredness or weakness
  • white patches in the mouth or on the tongue

Less common

  • Diarrhea
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • general feeling of discomfort or illness
  • hives, itching, skin rash
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shivering
  • sweating
  • tightness in the chest
  • trouble sleeping
  • vomiting


  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • rectal bleeding
  • redness of the skin
  • severe diarrhea
  • severe stomach pain

Some side effects of ixekizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to ixekizumab: subcutaneous solution


Common (1% to 10%): Urticaria

Uncommon (0.1% to 1%): Angioedema


Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Oral candidiasis, inflammatory bowel disease


Very common (10% or more): Neutropenia (11%)

Common (1% to 10%): Thrombocytopenia


Very common (10% or more): Infections (26%), immunogenicity (22%)

Common (1% to 10%): Tinea infections, influenza

Uncommon (0.1% to 1%): Serious infections


Very common (10% or more): Injection site reactions (17%), erythema, pain


Common (1% to 10%): Conjunctivitis


Very common (10% or more): Upper respiratory tract infections (including nasopharyngitis and rhinovirus infection) (14%)

Uncommon (0.1% to 1%): Rhinitis


Frequency not reported: Serious hypersensitivity reactions (e.g., anaphylaxis, angioedema, urticaria)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Taltz