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Generic Name: trandolapril and verapamil (tran DOL a pril and ver AP a mil)
Brand Name: Tarka
Physician reviewed Tarka patient information - includes Tarka description, dosage and directions.
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Drug Information:
Trandolapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Tarka is a combination medicine used to treat high blood pressure (hypertension). Tarka may also be used for purposes not listed in this medication guide. Do not use if you are pregnant. Stop using Tarka and tell your doctor right away if you become pregnant. You should not use this medicine if you have a heart rhythm disorder, low blood pressure, or a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker). Do not take Tarka within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). Learn more

Tarka Side Effects

Tarka Side Effects

Note: This document contains side effect information about trandolapril / verapamil. Some of the dosage forms listed on this page may not apply to the brand name Tarka.

In Summary

Common side effects of Tarka include: sinus bradycardia. Other side effects include: bradycardia, first degree atrioventricular block, and second degree atrioventricular block. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trandolapril / verapamil: oral tablet extended release


Oral route (Tablet, Extended Release)

Discontinue treatment with trandolapril/verapamil hydrochloride as soon as possible when pregnancy is detected, since fetal toxicity, including injury and death to the developing fetus, can be caused by drugs that act directly on the renin-angiotensin system.

Along with its needed effects, trandolapril / verapamil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trandolapril / verapamil:


  • Chest pain
  • chills
  • cough (with mucus)
  • dark urine
  • fever
  • general feeling of discomfort or illness
  • lightheadedness or fainting
  • pain in the right side of the abdomen or stomach
  • slow heartbeat
  • sore throat
  • swelling of the face, mouth, hands, or feet
  • trouble in swallowing or breathing (sudden) accompanied by hoarseness
  • yellow eyes or skin

Some side effects of trandolapril / verapamil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  • Constipation
  • cough (dry, continuous)
  • diarrhea
  • dizziness
  • itching
  • joint pain or pain in the arms or legs
  • nausea
  • unusual tiredness

For Healthcare Professionals

Applies to trandolapril / verapamil: oral tablet extended release


The most common adverse reactions were headache, upper respiratory tract infection, cough, atrioventricular block first degree, constipation, and dizziness.


Common (1% to 10%): Upper respiratory tract infection, cough, dyspnea, bronchitis, upper respiratory tract congestion

Frequency not reported: Epistaxis


Frequency not reported: Pulmonary edema


Common (1% to 10%): Asthenia/weakness, chest pain, edema, fatigue

Frequency not reported: Malaise


Frequency not reported: Gynecomastia


Common (1% to 10%): Constipation, nausea, diarrhea

Frequency not reported: Dyspepsia, dry mouth


Frequency not reported: Pancreatitis


Frequency not reported: Gingival hyperplasia, reversible nonobstructive paralytic ileus


Common (1% to 10%): Pain back, pain extremity, pain joint

Frequency not reported: Arthralgias/myalgias


Common (1% to 10%): Atrioventricular (AV) block first degree, bradycardia

Uncommon (0.1% to 1%): Hypotension

Frequency not reported: Angina, AV block second degree, bundle branch block, flushing, myocardial infarction, palpitation, premature ventricular contraction, nonspecific ST-T changes, tachycardia


Frequency not reported: Congestive heart failure, AV block third degree, AV dissociation, claudication, vasculitis

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Near syncope

Frequency not reported: Drowsiness, hypesthesia, loss of balance, paresthesia, vertigo, tinnitus


Frequency not reported: Syncope, cerebrovascular accident, shakiness, somnolence

Postmarketing reports: Tetraparesis

There has been one postmarketing report of paralysis (tetraparesis) with verapamil, which may have been caused by concomitant use of colchicine.


Common (1% to 10%): Creatinine increased

Uncommon (0.1% to 1%): BUN increased


Common (1% to 10%): Hyperlipidemia

Frequency not reported: Gout, uric acid increased, hyperkalemia, hyponatremia


Common (1% to 10%): Liver enzymes increased

Frequency not reported: Serum bilirubin increased


Common (1% to 10%): Influenza


Uncommon (0.1% to 1%): Angioedema

Frequency not reported: Pruritus, rash


Frequency not reported: Purpura, ecchymosis, exanthema, hair loss, hyperkeratosis, maculae, Stevens-Johnson syndrome, erythema multiform


Frequency not reported: Impotence, endometriosis, hematuria, nocturia, polyuria, proteinuria


Frequency not reported: Urination increased, menstruation spotty


Frequency not reported: Leukocytes decreased, neutrophils decreased, white blood cells low, neutrophils low, lymphocytes low, platelets low


Frequency not reported: Insomnia, anxiety, mentation abnormal


Frequency not reported: Libido decreased


Frequency not reported: Confusion, psychotic symptoms


Frequency not reported: Vision blurred



Frequency not reported: Galactorrhea/hyperprolactinemia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Tarka