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Generic Name: labetalol (la BAY ta lol)
Brand Name: Trandate
  • Prescription Settings

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Drug Information:
Trandate is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins). Trandate is used to treat hypertension (high blood pressure). Trandate may also be used for purposes not listed in this medication guide. You should not use Trandate if you have asthma or COPD, very low blood pressure, or a serious heart condition such as second or third degree heart block, severe heart failure, or very slow heartbeats. You should not take Trandate if you are allergic to it, or if you have: Learn more

Trandate Side Effects

Trandate Side Effects

Note: This document contains side effect information about labetalol. Some of the dosage forms listed on this page may not apply to the brand name Trandate.

For the Consumer

Applies to labetalol: oral tablet

Other dosage forms:

  • intravenous solution

Along with its needed effects, labetalol (the active ingredient contained in Trandate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking labetalol:

Less common

  • Blurred vision or other changes in vision
  • chills
  • cold sweats
  • confusion
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting position
  • shortness of breath
  • swelling of face, fingers, feet, or lower legs
  • tightness in chest
  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking labetalol:

Symptoms of overdose

  • Chest pain or discomfort
  • lightheadedness, dizziness, or fainting
  • slow or irregular heartbeat
  • sweating
  • unusual tiredness or weakness

Some side effects of labetalol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Nausea

Less common

  • Acid or sour stomach
  • belching
  • change in taste or bad, unusual, or unpleasant (after) taste
  • decreased interest in sexual intercourse
  • feeling of constant movement of self or surroundings
  • headache
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • not able to ejaculate semen
  • rash
  • sensation of spinning
  • stomach discomfort, upset, or pain
  • stuffy nose


  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • increased sweating
  • vomiting

For Healthcare Professionals

Applies to labetalol: compounding powder, intravenous solution, oral tablet


Common (1% to 10%): Edema, postural hypotension

Frequency not reported: Bradycardia, heart block, heart failure, hypotension, ankle edema, increase of an existing intermittent claudication, postural hypotension, cold or cyanotic extremities, Raynaud's phenomenon, paresthesia of the extremities, syncope


Uncommon (0.1% to 1%): Increased sweating

Frequency not reported: Systemic lupus erythematosus, rashes (e.g., generalized maculopapular, lichenoid, urticarial, bullous lichen planus, psoriaform, facial erythema, Peyronie's disease, reversible alopecia)


Frequency not reported: Masking of the normal response to hypoglycemia (sweating and tachycardia); this may be important in some patients with diabetes mellitus


Common (1% to 10%): Nausea, dyspepsia, vomiting

Uncommon (0.1% to 1%): Diarrhea

Frequency not reported: Epigastric pain


Common (1% to 10%): Ejaculation failure, impotence

Frequency not reported: Difficulty in micturition (including acute urinary bladder retention)


Common (1% to 10%): Transient elevations of liver function tests

Frequency not reported: Hepatic necrosis, hepatitis, cholestatic jaundice


Rare (less than 0.1%): Hypersensitivity (e.g., rash, urticaria, pruritus, angioedema, dyspnea), anaphylactoid reactions


Frequency not reported: Antimitochondrial antibodies


Very rare (less than 0.01%): Hyperkalemia


Frequency not reported: Muscle cramps, toxic myopathy

Nervous system

Very common (10% or more): Dizziness (11%)

Common (1% to 10%): Headache, taste distortion, vertigo, paresthesia, scalp tingling

Uncommon (0.1% to 1%): Drowsiness

Frequency not reported: Tremor


Common (1% to 10%): Vision abnormality

Frequency not reported: Dry eyes

Postmarketing reports: Intraoperative Floppy Iris Syndrome (IFIS) observed during cataract surgery


Common (1% to 10%): Nasal stuffiness, dyspnea

Frequency not reported: Bronchospasm, interstitial lung disease


Common (1% to 10%): Fatigue, asthenia

Frequency not reported: Positive antinuclear factor


Frequency not reported: Depressed mood and lethargy, hallucinations, psychoses, confusion, sleep disturbances, nightmares

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Trandate