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Generic Name: vortioxetine (VOR tye OX e teen)
Brand Names: Trintellix
Trintellix (vortioxetine) is an antidepressant used to treat major depressive disorder. Includes Trintellix side effects, interactions and indications.
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Drug Information:
Trintellix (vortioxetine) is a precription medicine that affects chemicals in the brain that may be unbalanced. Trintellix is an antidepressant that is used to treat major depressive disorder in adults. Trintellix may also be used for purposes not listed in this medication guide. Do not use Trintellix if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. After you stop taking Trintellix you must wait at least 21 days before you start taking an MAO inhibitor. Learn more

Trintellix Side Effects

Trintellix Side Effects

Note: This document contains side effect information about vortioxetine. Some of the dosage forms listed on this page may not apply to the brand name Trintellix.

In Summary

Common side effects of Trintellix include: diarrhea, male sexual disorder, and nausea. Other side effects include: constipation, dizziness, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vortioxetine: oral tablet


Oral route (Tablet)

Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies with major depressive disorder (MDD) and other psychiatric disorders. This risk must be balanced with the clinical need. Short term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared to placebo in adults aged 65 years or older. Monitor all patients closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Vortioxetine has not been evaluated for use in pediatric patients.

Along with its needed effects, vortioxetine (the active ingredient contained in Trintellix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vortioxetine:

Incidence not known

  • Agitation
  • blood in the stool or urine
  • confusion
  • convulsions
  • decreased urine output
  • diarrhea
  • dizziness
  • fast or irregular heartbeat
  • fever
  • headache
  • increased thirst
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • muscle pain or cramps
  • nausea or vomiting
  • nose bleeds
  • overactive reflexes
  • poor coordination
  • red or purple spots on the skin
  • restlessness
  • shivering
  • shortness of breath
  • sweating
  • swelling of the face, ankles, or hands
  • talking or acting with excitement you cannot control
  • trembling or shaking
  • twitching
  • unusual bruising
  • unusual tiredness or weakness
  • vomiting blood

Some side effects of vortioxetine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty having a bowel movement (stool)
  • dry mouth

Less common

  • Bloated or full feeling
  • excess air or gas in the stomach or intestines
  • itching skin
  • passing gas
  • unusual dreams

Incidence not known

  • Acid or sour stomach
  • belching
  • blurred vision
  • change in taste
  • dizziness or lightheadedness
  • eye pain
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • heartburn
  • indigestion
  • loss of taste
  • redness of the face, neck, arms, and occasionally, upper chest
  • sensation of spinning
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to vortioxetine: oral tablet


The most commonly reported side effects included nausea, sexual dysfunction, headache, diarrhea, and dry mouth.


Very common (10% or more): Nausea (up to 42%), constipation (up to 15%)

Common (1% to 10%): Abdominal discomfort, Diarrhea, dry mouth, dyspepsia, flatulence, gastroenteritis, upper abdominal pain, vomiting

Frequency not reported: Abdominal distention, epigastric discomfort, gastritis, salivary hypersecretion

Postmarketing reports: Acute pancreatitis

Nausea usually occurred during the first week of treatment, with up to 20% of patients reporting nausea within 1 to 2 days of starting treatment. Nausea occurred more frequently in female patients, and in patients 65 years and older.


Very common (10% or more): Sexual dysfunction (up to 34%)

Frequency not reported: Micturition urgency, nocturia, sexual desire, performance, and satisfaction

Nervous system

Very common (10% or more): Headache (up to 14.7%)

Common (1% to 10%): Dizziness, sedation, somnolence

Frequency not reported: Dysgeusia, formication, lethargy, myoclonus, serotonin syndrome, tremor, vertigo

Postmarketing reports: Seizure


Common (1% to 10%): Accidental overdose, asthenia, fatigue

Frequency not reported: Malaise


Common (1% to 10%): Abnormal dreams, insomnia

Uncommon (0.1% to 1%): Initial insomnia, middle insomnia, sleep disorder

Frequency not reported: Bruxism, derealization, dyssomnia, mood swings, poor quality sleep, restlessness, sudden outbursts of anger, tension, terminal insomnia, withdrawal symptoms


Common (1% to 10%): Generalized pruritus/pruritus, hyperhidrosis

Uncommon (0.1% to 1%): Flushing, night sweats

Frequency not reported: Rash

Postmarketing reports: Generalized rash


Common (1% to 10%): Arthralgia, back pain

Frequency not reported: Bone fractures, muscle tension


Common (1% to 10%): Decreased appetite

Frequency not reported: Hyponatremia, increased low density lipoprotein/blood cholesterol/blood triglycerides, weight gain


Common (1% to 10%): Nasopharyngitis


Common (1% to 10%): Influenza


Frequency not reported: Chest discomfort, hypotension, increased heart rate, prolonged electrocardiogram QT


Frequency not reported: Dry eye

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Trintellix