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Generic Name: Ethinyl Estradiol, Drospirenone, and Levomefolate (ETH in il es tra DYE ole, droh SPYE re none, & lee voe me FOE late)
Brand Name: Beyaz, Rajani, Safyral, Tydemy
Easy-to-read patient leaflet for Tydemy. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This is not a list of all drugs or health problems that interact with Tydemy (ethinyl estradiol, drospirenone, and levomefolate). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Tydemy (ethinyl estradiol, drospirenone, and levomefolate) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Learn more

Tydemy Side Effects

Tydemy Side Effects

Note: This document contains side effect information about drospirenone / ethinyl estradiol / levomefolate calcium. Some of the dosage forms listed on this page may not apply to the brand name Tydemy.

For the Consumer

Applies to drospirenone / ethinyl estradiol / levomefolate calcium: oral tablet


Oral route (Tablet)

Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs should not be used by women who are over 35 years of age and smoke.

Along with its needed effects, drospirenone / ethinyl estradiol / levomefolate calcium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking drospirenone / ethinyl estradiol / levomefolate calcium:

More common

  • Breast pain or tenderness
  • headache, severe and throbbing
  • heavy non-menstrual vaginal bleeding
  • irregular menstrual periods
  • nausea
  • normal menstrual bleeding occurring earlier, possibly lasting longer than expected

Less common

  • Longer or heavier menstrual periods
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Chills
  • clay-colored stools
  • dark urine
  • difficulty with breathing
  • dizziness
  • fever
  • headache
  • itching
  • loss of appetite
  • pain in the chest, groin, or legs, especially the calves
  • rash
  • slurred speech
  • stomach pain
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vision changes
  • vomiting of blood
  • yellow eyes or skin

Some side effects of drospirenone / ethinyl estradiol / levomefolate calcium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Crying
  • decreased interest in sexual intercourse
  • delusions of persecution, mistrust, suspiciousness, or combativeness
  • false or unusual sense of well-being
  • inability to have or keep an erection
  • irritability
  • loss in sexual ability, desire, drive, or performance
  • mental depression
  • quick to react or overreact emotionally
  • rapidly changing moods
  • weight gain

For Healthcare Professionals

Applies to drospirenone / ethinyl estradiol / levomefolate calcium: oral tablet


The more commonly reported adverse events include menstrual irregularities, nausea/vomiting, breast pain/tenderness, and headache/migraine.


Postmarketing reports: Venous and arterial thromboembolic events (including pulmonary emboli, deep vein thrombosis, cerebral thrombosis, retinal thrombosis, myocardial infarction and stroke), hypertension (including hypertensive crisis)


Combination Oral Contraceptives:

-Very Common (10% or more): Menstrual irregularities (up to 24.9%)

-Frequency not reported: Menstrual irregularities including vaginal hemorrhage (primarily spotting), metrorrhagia, menorrhagia, breast tenderness, decreased libido, unscheduled (breakthrough or intracyclic) bleeding

The average number of episodes of bleeding per 90 days was 3.2 in Cycles 4 to 6; the average number of bleeding and/or spotting days was 15.1 days. The intensity of bleeding based on the ratio of spotting-only days versus total bleeding and/or spotting days was 5.2/15.1 day.


Common (1% to 10%): Nausea, vomiting,

Postmarketing reports: Gallbladder disease, inflammatory bowel disease


Postmarketing reports: Hypersensitivity including anaphylactic reaction


Postmarketing reports: Liver function disturbances, liver tumors


Postmarketing reports: Hyperkalemia, hypertriglyceridemia, changes in glucose tolerance or effect on peripheral insulin resistance (including diabetes mellitus)

Nervous system

Common (1% to 10%): Migraine, headaches


Postmarketing reports: Retinal thrombosis


Frequency not reported: Irritability, depression, affect lability


Frequency not reported: Cervix carcinoma stage 0

Postmarketing reports: Cervical dysplasia


Postmarketing reports: Systemic lupus erythematosus


Postmarketing reports: Chloasma, angioedema, erythema nodosum, erythema multiforme


Common (1% to 10%): Fatigue

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Tydemy