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Zegerid otc

Zegerid OTC (omeprazole and sodium bicarbonate) is used to treat episodes of frequent heartburn. Includes Zegerid OTC side effects, interactions and indications.
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Drug Information:
The U.S. Food and Drug Administration (FDA) has approved Zegerid OTC (omeprazole 20 mg/sodium bicarbonate 1100 mg capsules), for over-the-counter treatment of frequent heartburn. Zegerid OTC is a proton pump inhibitor (PPI), the strongest and most effective class of acid-reducing medications available for frequent heartburn. Zegerid OTC treats frequent heartburn by controlling and suppressing acid for a full 24 hours, all day and all night. Zegerid OTC contains a patented dual-ingredient formulation that combines the prescription acid reducing medicine (omeprazole) with sodium bicarbonate, which protects the omeprazole from acid in the stomach. Learn more

Zegerid otc Side Effects

Zegerid OTC Side Effects

Note: This document contains side effect information about omeprazole / sodium bicarbonate. Some of the dosage forms listed on this page may not apply to the brand name Zegerid OTC.

In Summary

More frequent side effects include: congenital anomalies and abdominal pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to omeprazole / sodium bicarbonate: oral capsule, oral packet

Along with its needed effects, omeprazole/sodium bicarbonate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking omeprazole / sodium bicarbonate:

More common

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • chest pain
  • confusion
  • convulsions
  • cough
  • decreased urine
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fainting
  • fast or irregular heartbeat
  • fever or chills
  • headache
  • increased thirst
  • lightheadedness
  • loss of appetite
  • muscle pain or cramps
  • muscle spasms (tetany) or twitching
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid, shallow breathing
  • seizures
  • slow heartbeat
  • sneezing
  • sore throat
  • sweating
  • tightness in the chest
  • trembling
  • troubled breathing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Abdominal or stomach cramps or pain
  • bladder pain
  • blue lips, fingernails, or skin
  • bone pain
  • chest discomfort
  • cloudy urine
  • coma
  • decreased urine output
  • difficult or troubled breathing
  • difficult, burning, or painful urination
  • fast, pounding, or irregular heartbeat or pulse
  • frequent urge to urinate
  • headache
  • irregular, fast or slow, or shallow breathing
  • irritability
  • lower back or side pain
  • muscle cramps in the hands, arms, feet, legs, or face
  • restlessness
  • swelling
  • swelling of the face, feet, lower legs, ankles, or hands
  • weakness or heaviness of the legs


  • Severe pain in the chest
  • sudden onset of severe breathing difficulty

Incidence not known

  • Arm, back, or jaw pain
  • blistering, peeling, or loosening of the skin
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • chest tightness or heaviness
  • constipation
  • cough or hoarseness
  • dark-colored urine
  • diarrhea
  • difficulty with swallowing
  • fever with or without chills
  • general body swelling
  • general feeling of tiredness or weakness
  • greatly decreased frequency of urination or amount of urine
  • high fever
  • hives or skin rash
  • indigestion
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • noisy breathing
  • nosebleeds
  • pain with swallowing
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach pain, continuing
  • sweating
  • swollen glands
  • unexplained bleeding or bruising
  • unusual weight gain or loss
  • weight gain
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking omeprazole / sodium bicarbonate:

Symptoms of overdose

  • Feeling of warmth
  • increased sweating
  • redness of the face, neck, arms, and occasionally, upper chest

Some side effects of omeprazole / sodium bicarbonate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Agitation
  • cold sweats
  • cool, pale skin
  • depression
  • excess air or gas in the stomach or intestines
  • flushed, dry skin
  • fruit-like breath odor
  • full feeling
  • increased hunger
  • increased thirst
  • increased urination
  • lack or loss of strength
  • nightmares
  • passing gas
  • shakiness
  • slurred speech
  • white patches in the mouth or throat or on the tongue
  • white patches with diaper rash

Incidence not known

  • Abnormal dreams
  • attack, assault, or force
  • bad, unusual, or unpleasant (after) taste
  • blindness
  • blue-yellow color blindness
  • change in taste
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased vision
  • double vision
  • dry eyes or skin
  • eye pain
  • feeling of constant movement of self or surroundings
  • general feeling of discomfort or illness
  • hair loss or thinning of the hair
  • hearing loss
  • hives or welts
  • increased sensitivity of the skin to sunlight
  • itching, redness, tearing, or other sign of eye irritation not present before use of this medicine or becoming worse during use
  • lack of feeling or emotion
  • pain in the testes
  • pinpoint red or purple spots on the skin
  • redness or other discoloration of the skin
  • seeing, hearing, or feeling things that are not there
  • sensation of spinning
  • severe sunburn
  • sleepiness or unusual drowsiness
  • sugar in the urine
  • swelling of the breasts or breast soreness in both females and males
  • swelling or inflammation of the mouth
  • trouble sleeping
  • uncaring

For Healthcare Professionals

Applies to omeprazole / sodium bicarbonate: oral capsule, oral powder for reconstitution


Very common (10% or more): Pyrexia (Up to 20.2%)

Common (1% to 10%): Hyperpyrexia


Common (1% to 10%): Asthenia

Postmarketing reports: Fatigue, fever, malaise, pain, tinnitus


Very common (10% or more): Hypokalemia (Up to 12.4%), hyperglycemia NOS (Up to 10.7%), hypomagnesemia (Up to 10.1%)

Common (1% to 10%): Fluid overload, hyperkalemia, hypernatremia, hypocalcemia, hypoglycemia NOS, hyponatremia, hypophosphatemia


Postmarketing reports: Anorexia, hypoglycemia, hypomagnesemia, hyponatremia, weight gain

Sodium Bicarbonate:

Postmarketing reports: Metabolic acidosis, tetany


Very common (10% or more): Nosocomial pneumonia (Up to 11.2%)

Common (1% to 10%): Acute respiratory distress syndrome, respiratory failure

Uncommon (0.1% to 1%): Pneumothorax NOS


Common (1% to 10%): Cough, upper respiratory infection

Postmarketing reports: Bronchospasm, epistaxis, pharyngeal pain


Very common (10% or more): Thrombocytopenia (Up to 10.1%)

Common (1% to 10%): Anemia NOS, anemia NOS aggravated


Postmarketing reports: Agranulocytosis/fatal agranulocytosis, anemia, hemolytic anemia, leukocytosis, leukopenia, neutropenia, pancytopenia, thrombocytopenia


Common (1% to 10%): Atrial fibrillation, bradycardia not otherwise specified (NOS), edema NOS, hypertension NOS, hypotension NOS, supraventricular tachycardia, tachycardia NOS, ventricular tachycardia


Postmarketing reports: Bradycardia, chest pain/angina, elevated blood pressure, palpitation, peripheral edema, tachycardia


Common (1% to 10%): Constipation, diarrhea NOS, gastric hypomobility, oral candidiasis

Frequency not reported: Upper gastrointestinal bleeding


Common (1% to 10%): Abdominal pain, acid regurgitation, constipation, diarrhea, flatulence, nausea, vomiting

Postmarketing reports: Abdominal swelling, Clostridium difficile associated diarrhea, dry mouth, fecal discoloration, gastric fundic gland polyps, irritable colon, mucosal atrophy of the tongue, pancreatitis/fatal pancreatitis, stomatitis

Benign gastric fundic gland polyps occurred rarely and appeared to be reversible when omeprazole was discontinued.


Common (1% to 10%): Decubitus ulcer, rash NOS


Common (1% to 10%): Rash

Postmarketing reports: Alopecia, cutaneous lupus erythematosus, dry skin, erythema multiforme/severe erythema multiforme, hyperhidrosis, photosensitivity, pruritus, purpura and/or petechia with/without rechallenge, severe generalized skin reactions, skin inflammation, Stevens-Johnson syndrome, systemic lupus erythematosus, toxic epidermal necrolysis (TEN)/fatal TEN, urticaria


Common (1% to 10%): Abnormal liver function tests NOS


Postmarketing reports: Hepatic failure/fatal hepatic failure, hepatocellular/cholestatic/mixed hepatitis, jaundice, liver necrosis/fatal liver necrosis, mild to marked elevation of liver function tests (alkaline phosphatase, ALT, AST, gamma-glutamyl transpeptidase), overt liver disease


Common (1% to 10%): Candidal infection NOS, sepsis NOS


Common (1% to 10%): Agitation


Postmarketing reports: Abnormal dreams, aggression, agitation, anxiety, apathy, confusion, depression, hallucinations, insomnia, nervousness, psychiatric disturbances


Common (1% to 10%): Urinary tract infection NOS


Postmarketing reports: Hematuria, microscopic pyuria, proteinuria, testicular pain, urinary frequency, urinary tract infection

Nervous system


Common (1% to 10%): Headache, dizziness

Postmarketing reports: Hemifacial dysesthesia, hepatic encephalopathy, paresthesia, somnolence, taste perversion, tremors, vertigo

Sodium Bicarbonate:

Postmarketing reports: Seizures



Common (1% to 10%): Back pain

Postmarketing reports: Bone fracture, joint pain, leg pain, muscle cramps, muscle weakness, myalgia



Postmarketing reports: Anterior ischemic optic neuropathy, blurred vision, double vision, dry eye syndrome, ocular irritation, optic atrophy, optic neuritis



Postmarketing reports: Anaphylactic shock, anaphylaxis, angioedema, hypersensitivity reactions



Postmarketing reports: Elevated serum creatinine, glycosuria, interstitial nephritis with/without positive rechallenge



Postmarketing reports: Gastroduodenal carcinoids

Gastroduodenal carcinoids have been reported in patients with Zollinger-Ellison syndrome on long-term therapy. This condition may be a manifestation of the underlying condition, which is known to be associated with these tumors.



Postmarketing reports: Gynecomastia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Zegerid Otc