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Generic Name: goserelin (implant) (GOE se REL in)
Brand Names: Zoladex
Zoladex (goserelin) is used to treat endometriosis and breast cancer in women and prostate cancer on mean. Includes Zoladex side effects, interactions, indications
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Drug Information:
Zoladex (goserelin) is a man-made form of a hormone that regulates many processes in the body. Goserelin overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily. Zoladex is used in men to treat symptoms of prostate cancer. Zoladex is used in women to treat breast cancer or endometriosis. Goserelin is also used in women to prepare the lining of the uterus for endometrial ablation (a surgery to correct abnormal uterine bleeding). Zoladex can harm an unborn baby or cause birth defects. Unless you are being treated for advanced breast cancer, you should not use Zoladex during pregnancy. Use effective non-hormonal (barrier) birth control during treatment and for at least 12 weeks after treatment ends. Tell your doctor right away if you become pregnant during treatment. You should not breast-feed while you are using Zoladex. Learn more

Zoladex Side Effects

Zoladex Side Effects

Note: This document contains side effect information about goserelin. Some of the dosage forms listed on this page may not apply to the brand name Zoladex.

In Summary

Common side effects of Zoladex include: headache, vasodilation, and diaphoresis. Other side effects include: hypertension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to goserelin: subcutaneous implant

Along with its needed effects, goserelin (the active ingredient contained in Zoladex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking goserelin:

For all adults

Less common

  • Fast or irregular heartbeat


  • Bone, muscle, or joint pain
  • changes in skin color of the face
  • fainting
  • fast or irregular breathing
  • numbness or tingling of the hands or feet
  • puffiness or swelling of the eyelids or around the eyes
  • skin rash, hives, or itching
  • sudden, severe decrease in blood pressure and collapse
  • tightness in the chest
  • troubled breathing

For females only


  • Anxiety
  • deepening of voice
  • increased hair growth
  • mental depression
  • mood changes

For males only


  • Pain in the chest
  • pain in the groin or legs (especially in the calves of the legs)

Some side effects of goserelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For all adults

More common

  • Sudden sweating and feelings of warmth (also called hot flashes)

Less common

  • Blurred vision
  • burning, itching, redness, or swelling at the place of injection
  • decreased interest in sexual intercourse
  • dizziness
  • headache
  • nausea or vomiting
  • swelling and increased tenderness of the breasts
  • swelling of the feet or lower legs
  • trouble sleeping
  • weight gain

For females only

More common

  • Light, irregular vaginal bleeding
  • stopping of menstrual periods

Less common

  • Burning, dryness, or itching of the vagina
  • pelvic pain

For males only

Less common

  • Bone pain
  • constipation
  • decreased size of the testicles
  • inability to have or keep an erection

For Healthcare Professionals

Applies to goserelin: subcutaneous implant


Very common (10% or more): Sexual dysfunction (21%), erectile dysfunction (18%), lower urinary tract symptoms (13%), vaginitis, breast atrophy, breast enlargement

Common (1% to 10%): Gynecomastia, incontinence and urinary frequency (after radiotherapy), ureteric obstruction, pelvic pain

Uncommon (0.1% to 1%): Breast tenderness


Very common (10% or more): Libido decreased, emotional liability

Common (1% to 10%): Mood changes, depression, insomnia

Very rare (less than 0.01%): Psychotic disorder


Very common (10% or more): Hyperhidrosis, acne, seborrhea

Common (1% to 10%): Rash, pruritis

Frequency not reported: Alopecia


Very common (10% or more): Hot flashes (62%)

Common (1% to 10%): Cardiac failure, myocardial infarction, blood pressure abnormal

Frequency not reported: QT prolongation

Postmarketing reports: Deep vein thrombosis, stroke, transient ischemic attack

Nervous system

Very common (10% or more): Headache

Common (1% to 10%): Paresthesia, spinal cord compression, dizziness

Postmarketing reports: Convulsions


Very common (10% or more): Diarrhea (36%), cystitis (16%), rectal bleeding (14%)

Common (1% to 10%): Proctitis, vomiting


Very common (10% or more): Pharyngitis

Common (1% to 10%): Upper respiratory infection, chronic obstructive pulmonary disease


Uncommon (0.1% to 1%): Drug hypersensitivity

Rare (0.01% to 0.1%): Anaphylactic reaction


Common (1% to 10%): Bone pain, myalgia, leg cramps, hypertonia

Uncommon (0.1% to 1%): Arthralgia

Postmarketing reports: Osteoporosis, decreased bone mineral density and bone fracture in men


Common (1% to 10%): Glucose tolerance impaired, weight increased, anorexia


Common (1% to 10%): Hematuria


Very rare (less than 0.01%): Pituitary hemorrhage/infarction


Very rare (less than 0.01%): Pituitary tumor


Common (1% to 10%): Influenza syndrome


Common (1% to 10%): Injection site reaction


Common (1% to 10%): Lethargy, pain, edema

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Zoladex