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Generic Name: doxepin topical (DOX e pin TOP i kal)
Brand Name: Prudoxin, Zonalon
Physician reviewed Zonalon patient information - includes Zonalon description, dosage and directions.
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Drug Information:
Doxepin is a tricyclic antidepressant. When applied to the skin, Zonalon can help relieve itching but it will not treat symptoms of depression. Zonalon (for use on skin) is used to treat itchy skin in adults with eczema or other skin conditions that can lead to repeated scratching and thickened skin. Zonalon may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Learn more

Zonalon Side Effects

Zonalon Side Effects

Note: This document contains side effect information about doxepin topical. Some of the dosage forms listed on this page may not apply to the brand name Zonalon.

In Summary

Common side effects of Zonalon include: application site reaction and drowsiness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to doxepin topical: topical cream

Along with its needed effects, doxepin topical (the active ingredient contained in Zonalon) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking doxepin topical:

More common

  • Burning, crawling, or tingling sensation of the skin
  • swelling at the site of application
  • worsening of eczema and itching


  • Fever

Symptoms of overdose

  • Abdominal pain and swelling
  • blurring of vision
  • convulsions (seizures)
  • decreased awareness or responsiveness
  • difficulty in breathing
  • difficulty in passing urine
  • dizziness, fainting, or lightheadedness
  • drowsiness
  • enlarged pupils
  • excessive dryness of mouth
  • extremely high fever or body temperature
  • extremely low body temperature
  • fast heartbeat
  • increased or excessive unconscious or jerking movements
  • incurable constipation
  • irregular heartbeat
  • unconsciousness
  • vomiting
  • weak pulse

Some side effects of doxepin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Burning and/or stinging at the site of application
  • changes in taste
  • dizziness
  • drowsiness
  • dryness and tightness of skin
  • dryness of mouth and/or lips
  • emotional changes
  • headache
  • thirst
  • unusual tiredness or weakness

Less common

  • Anxiety
  • irritation, tingling, scaling, and cracking of skin
  • nausea

For Healthcare Professionals

Applies to doxepin topical: topical cream


Very common (10% or more): Burning/stinging (23%)

Common (1% to 10%): Other application site reaction

Frequency not reported: Irritation, tingling

Nervous system

Very common (10% or more): Drowsiness (up to 22%)

Common (1% to 10%): Dizziness, taste perversion

Uncommon (0.1% to 1%): Headache

Frequency not reported: Lightheadedness, taste bitter, taste metallic


Common (1% to 10%): Dry mouth

Uncommon (0.1% to 1%): Numbness of tongue, nausea

Frequency not reported: Dry lips, dry throat, thirst, indigestion, vomiting, diarrhea, constipation


Common (1% to 10%): Pruritus, eczema exacerbated

Frequency not reported: Localized rash, pruritus exacerbated

Postmarketing reports: Allergic contact dermatitis


The most frequently reported adverse effects were drowsiness and burning/stinging at application site.


Frequency not reported: Urinary retention


Frequency not reported: Type IV hypersensitivity reaction


Frequency not reported: Blurred vision, dry eyes


Common (1% to 10%): Fatigue/tiredness, edema

Uncommon (0.1% to 1%): Fever

Frequency not reported: Vertigo


Common (1% to 10%): Mental emotional changes

Uncommon (0.1% to 1%): Nervousness/anxiety

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Zonalon